Clinical Research Details Clinical Research HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma (HeadSMART II) Study Description The purpose of this research study is to develop and validate tests in order to aid in the diagnosis and prognosis of mild Traumatic Brain Injury (mTBI). Inclusion/Exclusion Criteria Inclusion Criteria 18 years and older Present to Emergency Department with blunt head trauma within 96 hours of injury Exclusion Criteria GCS < 13 at time of presentation Need for general anesthesia prior to enrollment Diagnosed with dementia requiring assistance for daily living Any head trauma requiring medical attention from a physician within the last 6 months Received chemotherapy or radiation within the last year History of stroke with disabling outcomes, brain tumor, epilepsy or intracranial surgery/hemorrhage Psychiatric hospitalization in the last 90 days Blood transfusion within the prior 4 weeks Cannot perform study tasks on an iPad (e.g. not wearing corrective lenses necessary to read, inability to use both hands) Investigators Phyllis L. Hendry, M.D., FAAP, FACEP Emergency Medicine