Clinical Research Details

Clinical Research

Posterior Fossa Decompression with or without Duraplasty for Chiari type I Malformation with Syringomyelia

Study Description

The purpose of this research study is to compare the two most common surgical treatments for Chiari type I malformation with syringomyelia, posterior fossa decompression without or with duraplasty, in terms of effectiveness, Quality of Life, and surgical complications or patient harm.

Inclusion/Exclusion Criteria

Inclusion Criteria

1) Age ≤21 years old 

2) Chiari malformation type I with ≥5 mm tonsillar ectopia 

3) Syrinx diameter (recorded as the greatest antero-posterior or transverse diameter) 3-9 mm. 

4) MRI of the brain and cervical and thoracic spine are required prior to surgery and available to be shared with the DCC PCORI CER-1503-29700 Version 6 March 01, 2021 17 

 

Exclusion Criteria 

1) Syrinx <3 mm and/or ≥10 mm 

2) Neuro-imaging demonstrating basilar invagination (position of the superior tip of dens ³5 mm above Chamberlain’s line) 

3) Neuro-imaging demonstrating clival canal angle <120° 

4) Prior PFD, PFDD, or other surgery at the craniovertebral junction 

5) CM+SM secondary to other pathology (e.g. a tumor) 

6) Unable to share pre-decompression MRI of the brain and cervical and thoracic spine 

7) Patients who do not wish to participate

Investigators