Clinical Research Details Clinical Research ACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Study Description To help combat COVID-19, this clinical trial will evaluate if repurposed from other Food and Drug Administration (FDA) indication medications can make participants feel better faster and reduce death and hospitalization. Inclusion/Exclusion Criteria Inclusion: - Greater than 30 years old - Confirmed SARS-CoV-2 infection by any authorized or approved polymerase chain reaction (PCR) or antigen test collected within 10 days of screening - Two or more current symptoms of acute infection for = 7 days. Symptoms include the following: fatigue, dyspnea, fever, cough, nausea, vomiting, diarrhea, body aches, chills, headache, sore throat, nasal symptoms, the new loss of sense of taste or smell. Exclusion: - Current or recent (within 10 days of screening) hospitalization for COVID-19. - Current use of study drug or study drug/device combination. - Known allergy/sensitivity or any hypersensitivity to components of the study drug or placebo. - Known contraindication(s) to the study drug including prohibited concomitant medications. Participation in the study will last about 3 months (90 days). All study visits can be remote (not in person). Participants will complete surveys online or by phone if they do not have access to a computer/tablet/smartphone or internet Open Enrollment Contact Name: Jennifer BowmanContact Phone: (904) 244-4691Contact Email: jennifer.bowman@jax.ufl.edu Investigators Carmen L. Isache, M.D. Medicine