Clinical Research Details Clinical Research Prevalence of Alcohol and Other Drug Use Among Motor Vehicle Crash Victims Study Description The purpose of this study is to examine the prevalence of legal and illegal drugs in the systems of seriously- or fatally-injured drivers and other crash-involved road users presenting directly to the trauma center or medical examiner. In addition, the study seeks to examine the prevalence of SARS-CoV-2 or related biological markers (e.g., antibodies) among trauma victims. De-identified blood samples that are already obtained during routine clinical treatment activities will be collected. The study will then conduct independent drug toxicology testing to determine the prevalence of alcohol, other drugs, and SARS-COV-2 or related antibodies. In addition, the study will obtain blood samples for patients admitted for other traumas in order to compare drug prevalence of drivers to other seriously injured highway system users (e.g., pedestrians, bicyclists, motor cycle riders) and victims of non-highway related traumas (e.g., falls, GSW). The trauma center and medical examiner will also provide the study with other de-identified participant classification information such as patient demographics, cause of injury, and injury severity. The trauma center and medical examiner will provide this already-collected and de-identified information to the study in accordance with all applicable Federal, State, and local regulations governing the sharing of such information and as approved by the study Institutional Review Board. Inclusion/Exclusion Criteria not applicable Investigators