Martin "M" Zenni M.D.

Associate Professor & Medical Director, Cardiovascular Off Campus Outreach Program; Medical Director of Nuclear Cardiology

Department: Department of Medicine

Business Phone: (904) 244-2655

Business Email: martin.zenni@jax.ufl.edu

Appointments and Locations

Board Certifications

Internal Medicine
Cardiovascular Disease
Interventional Cardiology
Nuclear Cardiology

Clinical Profile

Specialties

Cardiovascular Disease
Interventional Cardiology
Nuclear Cardiology

Interests

Clinical Special Interests: Coronary artery disease, atherosclerosis, hyperlipidemia and cardiac risk assessment; permanent pacemaker and hypothermia therapy for acute myocardial infarction; nuclear cardiology, antiplatelet and anticoagulant therapy
Research Special Interests: Coronary artery disease, atherosclerosis, hyperlipidemia and cardiac risk assessment, permanent pacemaker, and hypothermia therapy for acute myocardial infarction; nuclear cardiology, antiplatelet and anticoagulant therapy

Publications

2022

Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects of ticagrelor in patients with diabetes mellitus and coronary artery disease.

European heart journal. Cardiovascular pharmacotherapy.8(5):452-461[DOI] 10.1093/ehjcvp/pvab042.[PMID] 34114623.

2 citations·PubMed·Publisher's Site

2022

Pharmacodynamic Profiles of Dual-Pathway Inhibition with or without Clopidogrel versus Dual Antiplatelet Therapy in Patients with Atherosclerotic Disease.

Thrombosis and haemostasis.122(8):1341-1351[DOI] 10.1055/a-1730-8725.[PMID] 34983074.

2 citations·PubMed·Publisher's Site

2022

Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet therapy.

European heart journal. Cardiovascular pharmacotherapy.8(7):728-737[DOI] 10.1093/ehjcvp/pvac022.[PMID] 35353154.

2 citations·PubMed·Publisher's Site

2022

Swinging heart seen on single-photon emission computed tomography (SPECT).

BMJ case reports.15(6):-[DOI] 10.1136/bcr-2021-246487.[PMID] 35760503.

PubMed·Publisher's Site

2021

Impact of Timing of Pharmacodynamic Assessment on Platelet Reactivity in Patients Treated With Cangrelor.

JACC. Cardiovascular interventions.14(21):2410-2412[DOI] 10.1016/j.jcin.2021.07.051.[PMID] 34736741.

2 citations·PubMed·Publisher's Site

2020

Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.

Thrombosis and haemostasis.120(1):83-93[DOI] 10.1055/s-0039-1695772.[PMID] 31470444.

17 citations·PubMed·Publisher's Site

2020

Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.

Circulation.142(15):1500-1502[DOI] 10.1161/CIRCULATIONAHA.120.048770.[PMID] 33044856.

9 citations·PubMed·Publisher's Site

2020

Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12 Receptor Inhibitors With and Without Aspirin: Results of the VORA-PRATIC Study.

Journal of the American Heart Association.9(8):e015865-[DOI] 10.1161/JAHA.120.015865.[PMID] 32306797.

15 citations·PubMed·Publisher's Site

2020

Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.

JACC. Basic to translational science.5(5):419-428[DOI] 10.1016/j.jacbts.2020.02.009.[PMID] 32478205.

16 citations·PubMed·Publisher's Site

2019

Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.

JACC. Cardiovascular interventions.12(16):1538-1549[DOI] 10.1016/j.jcin.2019.05.028.[PMID] 31377269.

20 citations·PubMed·Publisher's Site

2019

Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.

JACC. Basic to translational science.4(7):763-775[DOI] 10.1016/j.jacbts.2019.07.011.[PMID] 31998847.

11 citations·PubMed·Publisher's Site

2019

Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Circulation.139(14):1661-1670[DOI] 10.1161/CIRCULATIONAHA.118.038317.[PMID] 30630341.

75 citations·PubMed·Publisher's Site

2018

Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.

Circulation.137(23):2450-2462[DOI] 10.1161/CIRCULATIONAHA.118.033983.[PMID] 29526833.

42 citations·PubMed·Publisher's Site

2017

Impact of chronic kidney disease on platelet P2Y12 receptor signalling in patients with type 2 diabetes mellitus.

Thrombosis and haemostasis.117(1):201-203[DOI] 10.1160/TH16-08-0594.[PMID] 27786340.

6 citations·PubMed·Publisher's Site

2017

Should endovascular approach be the first line of treatment for retroperitoneal bleeding with hemodynamic shock following percutaneous intervention? A case series.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.90(1):104-111[DOI] 10.1002/ccd.26775.[PMID] 27566914.

7 citations·PubMed·Publisher's Site

2016

A head-to-head pharmacodynamic comparison of prasugrel vs. ticagrelor after switching from clopidogrel in patients with coronary artery disease: results of a prospective randomized study.

European heart journal.37(35):2722-30[DOI] 10.1093/eurheartj/ehv744.[PMID] 26848148.

49 citations·PubMed·Publisher's Site

2016

Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study.

Journal of the American College of Cardiology.67(17):1994-2004[DOI] 10.1016/j.jacc.2016.02.045.[PMID] 27012781.

87 citations·PubMed·Publisher's Site

2016

Effects of dabigatran on the cellular and protein phase of coagulation in patients with coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. Results from a prospective, randomised, double-blind, placebo-controlled study.

Thrombosis and haemostasis.115(3):622-31[DOI] 10.1160/TH15-06-0467.[PMID] 26633836.

21 citations·PubMed·Publisher's Site

2016

Impact of timing from blood sampling to pharmacodynamic assessment on measures of platelet reactivity in patients treated with P2Y12 receptor inhibitors.

Thrombosis and haemostasis.116(6):1060-1069[DOI] .[PMID] 27488362.

6 citations·PubMed·Publisher's Site

2016

Pharmacodynamic Comparison of Prasugrel Versus Ticagrelor in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 Study.

Circulation.134(11):780-92[DOI] 10.1161/CIRCULATIONAHA.116.023402.[PMID] 27559041.

73 citations·PubMed·Publisher's Site

2016

Pharmacodynamic Effects of Switching From Prasugrel to Ticagrelor: Results of the Prospective, Randomized SWAP-3 Study.

JACC. Cardiovascular interventions.9(11):1089-98[DOI] 10.1016/j.jcin.2016.02.039.[PMID] 27013060.

31 citations·PubMed·Publisher's Site

2015

Impact of Escalating Loading Dose Regimens of Ticagrelor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of a Prospective Randomized Pharmacokinetic and Pharmacodynamic Investigation.

JACC. Cardiovascular interventions.8(11):1457-1467[DOI] 10.1016/j.jcin.2015.02.030.[PMID] 26404199.

64 citations·PubMed·Publisher's Site

2015

Pharmacodynamic Effects of Ticagrelor Dosing Regimens in Patients on Maintenance Ticagrelor Therapy: Results From a Prospective, Randomized, Double-Blind Investigation.

JACC. Cardiovascular interventions.8(8):1075-1083[DOI] 10.1016/j.jcin.2015.02.022.[PMID] 26117466.

4 citations·PubMed·Publisher's Site

2015

Pooled comparison of regadenoson versus adenosine for measuring fractional flow reserve and coronary flow in the catheterization laboratory.

Cardiovascular revascularization medicine : including molecular interventions.16(5):266-71[DOI] 10.1016/j.carrev.2015.05.011.[PMID] 26242981.

11 citations·PubMed·Publisher's Site

2014

Cigarette smoking and antiplatelet effects of aspirin monotherapy versus clopidogrel monotherapy in patients with atherosclerotic disease: results of a prospective pharmacodynamic study.

Journal of cardiovascular translational research.7(1):53-63[DOI] 10.1007/s12265-013-9535-3.[PMID] 24395495.

21 citations·PubMed·Publisher's Site

2014

Operator radiation exposure and physical discomfort during a right versus left radial approach for coronary interventions: a randomized evaluation.

JACC. Cardiovascular interventions.7(7):810-6[DOI] 10.1016/j.jcin.2013.11.026.[PMID] 24954573.

29 citations·PubMed·Publisher's Site

2014

Pharmacodynamic effects of cangrelor on platelet P2Y12 receptor-mediated signaling in prasugrel-treated patients.

JACC. Cardiovascular interventions.7(4):426-34[DOI] 10.1016/j.jcin.2013.11.019.[PMID] 24630878.

27 citations·PubMed·Publisher's Site

2013

Effects of Cangrelor in Prasugrel Treated Patients: a Pharmacodynamic in Vitro Investigation

Circulation.128(22, S):-[DOI] .[PMID] .

PubMed·Publisher's Site

2013

Operator Radiation Exposure and Physical Discomfort During a Right Versus Left Radial Approach for Coronary Interventions: a Randomized Evaluation

Journal of the American College of Cardiology.61():E1683-[DOI] .[PMID] .

PubMed·Publisher's Site

2012

Effects of Pioglitazone On Platelet P2Y12 Mediated Signaling in Clopidogrel Treated Patients With Type 2 Diabetes Mellitus

Journal of the American College of Cardiology.59():E263-[DOI] .[PMID] .

PubMed·Publisher's Site

2012

Effects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patients with type 2 diabetes mellitus.

Thrombosis and haemostasis.108(5):930-6[DOI] 10.1160/TH12-06-0397.[PMID] 22782352.

12 citations·PubMed·Publisher's Site

2012

Pharmacodynamic Effects of Prasugrel Dosing Regimens in Patients On Maintenance Prasugrel Therapy: Results of a Prospective Randomized Study

Journal of the American College of Cardiology.59():E270-[DOI] .[PMID] .

PubMed·Publisher's Site

2012

Pharmacodynamic effects of prasugrel dosing regimens in patients on maintenance prasugrel therapy: results of a prospective randomized study.

Journal of the American College of Cardiology.59(19):1681-7[DOI] 10.1016/j.jacc.2011.12.039.[PMID] 22554598.

15 citations·PubMed·Publisher's Site

2012

Radial Access: Is There An Increased Risk of Operator Radiation Exposure During a Right Versus Left Radial Approach?

Journal of the American College of Cardiology.60():B117-[DOI] .[PMID] .

PubMed·Publisher's Site

2011

Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy.

Thrombosis and haemostasis.106(2):253-62[DOI] 10.1160/TH11-01-0041.[PMID] 21614414.

32 citations·PubMed·Publisher's Site

2011

Transradial Approach To Coronary Interventions: How Steep Is the Learning Curve for Trained Interventional Cardiologists?

Journal of the American College of Cardiology.58():B141-B142[DOI] .[PMID] .

PubMed·Publisher's Site

2009

Antiplatelet Drug Response Variability and the Role of Platelet Function Testing: a Practical Guide for Interventional Cardiologists

Catheterization and cardiovascular interventions..73(1):1-14[DOI] 10.1002/ccd.21782.[PMID] 19089929.

28 citations·PubMed·Publisher's Site

2009

Clopidogrel-Induced Antiplatelet Effect Assessment By Flow Cytometry and Point-Of-Care Based Assays: Correlation Between Vasp and Verifynow P2Y(12) Testing

Journal of the American College of Cardiology.53():A71-[DOI] .[PMID] .

PubMed·Publisher's Site

2009

Evaluation of a Modified Light Transmittance Aggregometry Protocol To Assess P2Y(12) Blockade Induced By Clopidogrel

Journal of the American College of Cardiology.53():A71-[DOI] .[PMID] .

PubMed·Publisher's Site

2009

Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients.

Thrombosis research.124(3):318-22[DOI] 10.1016/j.thromres.2008.10.001.[PMID] 19012950.

33 citations·PubMed·Publisher's Site

2008

A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.

European heart journal.29(18):2202-11[DOI] 10.1093/eurheartj/ehn287.[PMID] 18567918.

160 citations·PubMed·Publisher's Site

2008

A systematic review of outcomes in patients with staged carotid artery stenting and coronary artery bypass graft surgery.

Stroke.39(2):361-5[DOI] 10.1161/STROKEAHA.107.495010.[PMID] 18174484.

42 citations·PubMed·Publisher's Site

2008

Association of Heart Failure Class and Left Ventricular Dyssynchrony Measured By Spect Imaging in Ischemic Systolic Heart Failure Patients

Journal of Cardiac Failure.14(6):S90-[DOI] 10.1016/j.cardfail.2008.06.246.[PMID] .

PubMed·Publisher's Site

2008

Association of Ventricular Arrhythmia Therapy and Extent of Scarred Myocardium Measured By Single-Photon Emission Computed Tomography Imaging in Ischemic Systolic Heart Failure Patients

Journal of Cardiac Failure.14(6):S58-[DOI] 10.1016/j.cardfail.2008.06.306.[PMID] .

PubMed·Publisher's Site

2008

Functional effects of high clopidogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment.

The American journal of cardiology.101(4):440-5[DOI] 10.1016/j.amjcard.2007.09.087.[PMID] 18312754.

61 citations·PubMed·Publisher's Site

2008

Functional impact of high clopidogrel maintenance dosing in patients undergoing elective percutaneous coronary interventions. Results of a randomized study.

Thrombosis and haemostasis.99(1):161-8[DOI] 10.1160/TH07-09-0562.[PMID] 18217149.

65 citations·PubMed·Publisher's Site

2008

Impact of the Degree of Platelet Function On Thrombin Generation Profiles in Patients With Type 2 Diabetes Mellitus

Journal of the American College of Cardiology.51():A193-[DOI] .[PMID] .

PubMed·Publisher's Site

2008

Variable histological and ultrasonic characteristics of restenosis after drug-eluting stents.

International journal of cardiology.130(3):444-8[DOI] 10.1016/j.ijcard.2007.08.143.[PMID] 18199506.

13 citations·PubMed·Publisher's Site

2007

Anatomical and physiologic assessments in patients with small coronary artery disease: final results of the Physiologic and Anatomical Evaluation Prior to and After Stent Implantation in Small Coronary Vessels (PHANTOM) trial.

American heart journal.153(2):296.e1-7[DOI] .[PMID] 17239692.

46 citations·PubMed·Publisher's Site

2007

Quantitative magnetic resonance perfusion imaging detects anatomic and physiologic coronary artery disease as measured by coronary angiography and fractional flow reserve.

Journal of the American College of Cardiology.50(6):514-22[DOI] .[PMID] 17678734.

104 citations·PubMed·Publisher's Site

2007

Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study.

Circulation.115(6):708-16[DOI] .[PMID] 17261652.

389 citations·PubMed·Publisher's Site

2006

Intravascular ultrasound characterization of the "black hole" phenomenon after drug-eluting stent implantation.

The American journal of cardiology.97(2):203-6[DOI] .[PMID] 16442364.

22 citations·PubMed·Publisher's Site

2005

Sirolimus-eluting stents for treatment of complex bypass graft disease: insights from the SECURE registry.

The Journal of invasive cardiology.17(8):396-8[DOI] .[PMID] 16079441.

11 citations·PubMed·Publisher's Site

2004

Multiple plaque morphologies in a single coronary artery: insights from volumetric intravascular ultrasound.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.61(3):376-80[DOI] .[PMID] 14988899.

10 citations·PubMed·Publisher's Site

2004

Synergistic use of sirolimus-eluting stents and intravascular ultrasound for the treatment of unprotected left main and vein graft disease.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.61(3):368-75[DOI] .[PMID] 14988898.

6 citations·PubMed·Publisher's Site

2003

Debulking does not benefit patients undergoing intracoronary beta-radiation therapy for in-stent restenosis: insights from the START trial.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.58(3):331-5[DOI] .[PMID] 12594697.

11 citations·PubMed·Publisher's Site

2002

Intravascular ultrasound catheter entrapment after coronary artery stenting.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.57(2):229-33[DOI] .[PMID] 12357527.

14 citations·PubMed·Publisher's Site