Alaa S. Awad M.D. Professor & Medical Director, Dialysis Unit Department: Department of Medicine Business Phone: (904) 244-5964 Business Email: Alaa.Awad@jax.ufl.edu Appointments and Locations Board Certifications Internal MedicineNephrology Show More Clinical Profile Specialties Nephrology Show More Publications 2025Early Versus Late Initiation of Dialysis in CKD Stage 5: Time for a Consensus.Kidney international reports.10(1):54-74[DOI] 10.1016/j.ekir.2024.10.001.[PMID] 39810788.PubMed·Publisher's Site2024Comparative effectiveness of an individualized model of hemodialysis vs conventional hemodialysis: a study protocol for a multicenter randomized controlled trial (the TwoPlus trial).Trials.25(1):424-[DOI] 10.1186/s13063-024-08281-9.[PMID] 38943204.1 citations·PubMed·Publisher's Site2024Glucagon-like Peptide-1 Receptor Agonists and Diabetic Kidney Disease: From Bench to Bed-Side.Journal of clinical medicine.13(24):-[DOI] 10.3390/jcm13247732.[PMID] 39768655.1 citations·PubMed·Publisher's Site2024SGLT2 inhibitors: Beyond glycemic control.Journal of clinical & translational endocrinology.35():100335-[DOI] 10.1016/j.jcte.2024.100335.[PMID] 38525377.17 citations·PubMed·Publisher's Site2024Sodium-Glucose Co-Transporter 2 Inhibitors: Mechanism of Action and Efficacy in Non-Diabetic Kidney Disease from Bench to Bed-Side.Journal of clinical medicine.13(4):-[DOI] 10.3390/jcm13040956.[PMID] 38398269.7 citations·PubMed·Publisher's Site2023Acute Kidney Injury: Medical Causes and Pathogenesis.Journal of clinical medicine.12(1):-[DOI] 10.3390/jcm12010375.[PMID] 36615175.65 citations·PubMed·Publisher's Site2023Clinical Advances in Kidney Failure: AKI.Journal of clinical medicine.12(5):-[DOI] 10.3390/jcm12051873.[PMID] 36902660.PubMed·Publisher's Site2023Nonsteroidal Mineralocorticoid Receptor Antagonist (Finerenone) in Cardiorenal Disease.Journal of clinical medicine.12(19):-[DOI] 10.3390/jcm12196285.[PMID] 37834929.8 citations·PubMed·Publisher's Site2022Optimum Post-Discharge Care of Acute Kidney Injury (AKI) Survivors.Journal of clinical medicine.11(21):-[DOI] 10.3390/jcm11216277.[PMID] 36362503.2 citations·PubMed·Publisher's Site2021Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase-3.Physiological reports.9(5):e14766-[DOI] 10.14814/phy2.14766.[PMID] 33713581.7 citations·PubMed·Publisher's Site2021Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors.Nature reviews. Nephrology.17(5):319-334[DOI] 10.1038/s41581-021-00393-8.[PMID] 33547417.350 citations·PubMed·Publisher's Site2020Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.American journal of physiology. Renal physiology.318(2):F509-F517[DOI] 10.1152/ajprenal.00518.2019.[PMID] 31904280.14 citations·PubMed·Publisher's Site2020Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis.JCI insight.5(19):-[DOI] 10.1172/jci.insight.142187.[PMID] 32956070.17 citations·PubMed·Publisher's Site2019l-Homoarginine supplementation prevents diabetic kidney damage.Physiological reports.7(18):e14235-[DOI] 10.14814/phy2.14235.[PMID] 31552707.17 citations·PubMed·Publisher's Site2017Arginase-2 mediates renal ischemia-reperfusion injury.American journal of physiology. Renal physiology.313(2):F522-F534[DOI] 10.1152/ajprenal.00620.2016.[PMID] 28515179.12 citations·PubMed·Publisher's Site2017Distinct roles of arginases 1 and 2 in diabetic nephropathy.American journal of physiology. Renal physiology.313(4):F899-F905[DOI] 10.1152/ajprenal.00158.2017.[PMID] 28446459.8 citations·PubMed·Publisher's Site2017Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.Kidney international.91(3):671-682[DOI] 10.1016/j.kint.2016.09.042.[PMID] 27914709.27 citations·PubMed·Publisher's Site2015Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy.American journal of physiology. Renal physiology.309(5):F447-55[DOI] 10.1152/ajprenal.00137.2015.[PMID] 26041444.26 citations·PubMed·Publisher's Site2015Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury.PloS one.10(7):e0133777-[DOI] 10.1371/journal.pone.0133777.[PMID] 26207369.9 citations·PubMed·Publisher's Site2015Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury.Kidney international.88(4):722-33[DOI] 10.1038/ki.2015.162.[PMID] 26061548.152 citations·PubMed·Publisher's Site2015Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice.Chemical research in toxicology.28(7):1427-33[DOI] 10.1021/acs.chemrestox.5b00097.[PMID] 26034881.15 citations·PubMed·Publisher's Site2014Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.American journal of physiology. Renal physiology.307(11):F1292-301[DOI] 10.1152/ajprenal.00176.2014.[PMID] 25320354.27 citations·PubMed·Publisher's Site2013Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism.Kidney international.84(6):1189-97[DOI] 10.1038/ki.2013.215.[PMID] 23760286.45 citations·PubMed·Publisher's Site2013Macrophages directly mediate diabetic renal injury.American journal of physiology. Renal physiology.305(12):F1719-27[DOI] 10.1152/ajprenal.00141.2013.[PMID] 24173355.132 citations·PubMed·Publisher's Site2013Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury.American journal of physiology. Renal physiology.305(6):F891-900[DOI] 10.1152/ajprenal.00149.2013.[PMID] 23884140.21 citations·PubMed·Publisher's Site2012Management of Diabetic Nephropathy in the Elderly: Special Considerations.Journal of nephrology & therapeutics.2(5):-[DOI] .[PMID] 24010011.5 citations·PubMed·Publisher's Site2012Therapeutic Modalities in Diabetic Nephropathy: Future Approaches.Open journal of nephrology.2(2):5-18[DOI] .[PMID] 23293752.11 citations·PubMed·Publisher's Site2012Therapeutic modalities in diabetic nephropathy: standard and emerging approaches.Journal of general internal medicine.27(4):458-68[DOI] 10.1007/s11606-011-1912-5.[PMID] 22005942.47 citations·PubMed·Publisher's Site2011Arginase-2 mediates diabetic renal injury.Diabetes...60(11):3015-22[DOI] 10.2337/db11-0901.[PMID] 21926276.77 citations·PubMed·Publisher's Site2011Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.Kidney international.79(10):1090-8[DOI] 10.1038/ki.2010.544.[PMID] 21289599.82 citations·PubMed·Publisher's Site2011Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.American journal of physiology. Renal physiology.301(6):F1358-66[DOI] 10.1152/ajprenal.00332.2011.[PMID] 21880831.97 citations·PubMed·Publisher's Site2009Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.Kidney international.75(7):689-98[DOI] 10.1038/ki.2008.648.[PMID] 19129795.185 citations·PubMed·Publisher's Site2009Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.Kidney international.75(2):167-75[DOI] 10.1038/ki.2008.400.[PMID] 18971925.66 citations·PubMed·Publisher's Site2008Activation of adenosine 2A receptors preserves structure and function of podocytes.Journal of the American Society of Nephrology : JASN.19(1):59-68[DOI] .[PMID] 18045850.46 citations·PubMed·Publisher's Site2007Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.Journal of immunology (Baltimore, Md. : 1950).178(7):4240-9[DOI] .[PMID] 17371980.110 citations·PubMed·Publisher's Site2007Distant organ injury following acute kidney injury.American journal of physiology. Renal physiology.293(1):F28-9[DOI] .[PMID] 17429033.24 citations·PubMed·Publisher's Site2007Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury.American journal of physiology. Lung cellular and molecular physiology.293(1):L105-13[DOI] .[PMID] 17416740.96 citations·PubMed·Publisher's Site2006Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy.American journal of physiology. Renal physiology.290(4):F828-37[DOI] .[PMID] 16332931.125 citations·PubMed·Publisher's Site2006Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.American journal of physiology. Renal physiology.290(6):F1516-24[DOI] .[PMID] 16403835.198 citations·PubMed·Publisher's Site2005Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.American journal of hypertension.18(4 Pt 1):544-8[DOI] .[PMID] 15831366.13 citations·PubMed·Publisher's Site2004Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.Journal of hypertension.22(8):1571-7[DOI] .[PMID] 15257181.26 citations·PubMed·Publisher's Site2003The angiotensin II type 1 receptor mediates renal interstitial content of tumor necrosis factor-alpha in diabetic rats.Endocrinology.144(6):2229-33[DOI] .[PMID] 12746279.50 citations·PubMed·Publisher's Site2003Urinary and renal interstitial concentrations of TNF-alpha increase prior to the rise in albuminuria in diabetic rats.Kidney international.64(4):1208-13[DOI] .[PMID] 12969138.135 citations·PubMed·Publisher's Site Show More Office Information Academic Office 4th Floor, ACC Building655 West 8th StreetJacksonville, FL 32209(904) 244-4502 Alaa.Awad@jax.ufl.edu Administrative Manager Sandy Caroccio(904) 244-5964casandra.caroccio@jax.ufl.edu Administrative Manager Rochelly Ortiz(904) 244-8846rochelly.ortiz@jax.ufl.edu Show More Clinical Research Comparative effectiveness of early vs. late initiation of dialysis in chronic kidney disease stage 5 with eGFR = 10 OPEN ENROLLMENT The TwoPlus Study-Comparative Effectiveness of an Individualized Model of Hemodialysis vs. Conventional Hemodialysis Education Medical Degree1997 · Cairo University, Cairo, EgyptInternal Medicine Residency2017 · Penn State Milton S. Hershey Medical Center, Hershey, PA, USANephrology Fellowship2019 · University of Texas Health Science Center, San Antonio, TX, USA Show More