Alaa S. Awad, M.D.

Alaa S. Awad M.D.

Professor & Medical Director, Dialysis Unit

Department: Department of Medicine
Business Phone: (904) 244-5964
Business Email: Alaa.Awad@jax.ufl.edu

Board Certifications

  • Internal Medicine
  • Nephrology

Clinical Profile

Specialties
  • Nephrology

Publications

2021
Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3
Physiological Reports.9(5):-[DOI] 10.14814/phy2.14766.[PMID] 33713581.
2021
Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors
Nature Reviews Nephrology.17(5):319-334[DOI] 10.1038/s41581-021-00393-8.[PMID] .
2020
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy.
American journal of physiology. Renal physiology.318(2):F509-F517[DOI] 10.1152/ajprenal.00518.2019.[PMID] 31904280.
2020
Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis
JCI Insight.5(19):-[DOI] 10.1172/jci.insight.142187.[PMID] 32956070.
2019
l ‐Homoarginine supplementation prevents diabetic kidney damage
Physiological Reports.7(18):-[DOI] 10.14814/phy2.14235.[PMID] 31552707.
2017
Arginase-2 mediates renal ischemia-reperfusion injury.
American journal of physiology. Renal physiology.313(2):F522-F534[DOI] 10.1152/ajprenal.00620.2016.[PMID] 28515179.
2017
Distinct roles of arginases 1 and 2 in diabetic nephropathy.
American journal of physiology. Renal physiology.313(4):F899-F905[DOI] 10.1152/ajprenal.00158.2017.[PMID] 28446459.
2017
Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.
Kidney international.91(3):671-682[DOI] 10.1016/j.kint.2016.09.042.[PMID] 27914709.
2015
Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy.
American journal of physiology. Renal physiology.309(5):F447-55[DOI] 10.1152/ajprenal.00137.2015.[PMID] 26041444.
2015
Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury.
PloS one.10(7):e0133777-[DOI] 10.1371/journal.pone.0133777.[PMID] 26207369.
2015
Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury.
Kidney international.88(4):722-33[DOI] 10.1038/ki.2015.162.[PMID] 26061548.
2015
Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice.
Chemical research in toxicology.28(7):1427-33[DOI] 10.1021/acs.chemrestox.5b00097.[PMID] 26034881.
2014
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.
American journal of physiology. Renal physiology.307(11):F1292-301[DOI] 10.1152/ajprenal.00176.2014.[PMID] 25320354.
2013
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism.
Kidney international.84(6):1189-97[DOI] 10.1038/ki.2013.215.[PMID] 23760286.
2013
Macrophages directly mediate diabetic renal injury.
American journal of physiology. Renal physiology.305(12):F1719-27[DOI] 10.1152/ajprenal.00141.2013.[PMID] 24173355.
2013
Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury.
American journal of physiology. Renal physiology.305(6):F891-900[DOI] 10.1152/ajprenal.00149.2013.[PMID] 23884140.
2012
Management of Diabetic Nephropathy in the Elderly: Special Considerations.
Journal of nephrology & therapeutics.2(5):-[DOI] .[PMID] 24010011.
2012
Therapeutic Modalities in Diabetic Nephropathy: Future Approaches.
Open journal of nephrology.2(2):5-18[DOI] .[PMID] 23293752.
2012
Therapeutic modalities in diabetic nephropathy: standard and emerging approaches.
Journal of general internal medicine.27(4):458-68[DOI] 10.1007/s11606-011-1912-5.[PMID] 22005942.
2011
Arginase-2 mediates diabetic renal injury.
Diabetes.60(11):3015-22[DOI] 10.2337/db11-0901.[PMID] 21926276.
2011
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes.
Kidney international.79(10):1090-8[DOI] 10.1038/ki.2010.544.[PMID] 21289599.
2011
Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.
American journal of physiology. Renal physiology.301(6):F1358-66[DOI] 10.1152/ajprenal.00332.2011.[PMID] 21880831.
2009
Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury.
Kidney international.75(7):689-98[DOI] 10.1038/ki.2008.648.[PMID] 19129795.
2009
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.
Kidney international.75(2):167-75[DOI] 10.1038/ki.2008.400.[PMID] 18971925.
2008
Activation of adenosine 2A receptors preserves structure and function of podocytes.
Journal of the American Society of Nephrology : JASN.19(1):59-68[DOI] .[PMID] 18045850.
2008
Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease.
Kidney international.73(11):1220-30[DOI] 10.1038/ki.2008.34.[PMID] 18322542.
2007
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition.
Journal of immunology (Baltimore, Md. : 1950).178(7):4240-9[DOI] .[PMID] 17371980.
2007
Distant organ injury following acute kidney injury.
American journal of physiology. Renal physiology.293(1):F28-9[DOI] .[PMID] 17429033.
2007
Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury.
American journal of physiology. Lung cellular and molecular physiology.293(1):L105-13[DOI] .[PMID] 17416740.
2006
Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy.
American journal of physiology. Renal physiology.290(4):F828-37[DOI] .[PMID] 16332931.
2006
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
American journal of physiology. Renal physiology.290(6):F1516-24[DOI] .[PMID] 16403835.
2005
Increased renal production of angiotensin II and thromboxane B2 in conscious diabetic rats.
American journal of hypertension.18(4 Pt 1):544-8[DOI] .[PMID] 15831366.
2004
Renal nitric oxide production is decreased in diabetic rats and improved by AT1 receptor blockade.
Journal of hypertension.22(8):1571-7[DOI] .[PMID] 15257181.
2003
The angiotensin II type 1 receptor mediates renal interstitial content of tumor necrosis factor-alpha in diabetic rats.
Endocrinology.144(6):2229-33[DOI] .[PMID] 12746279.
2003
Urinary and renal interstitial concentrations of TNF-alpha increase prior to the rise in albuminuria in diabetic rats.
Kidney international.64(4):1208-13[DOI] .[PMID] 12969138.

Office Information

Academic Office
4th Floor, ACC Building
655 West 8th Street
Jacksonville, FL 32209
(904) 244-4502
Alaa.Awad@jax.ufl.edu
Senior Medical Secretary
Sandy Caroccio
(904) 244-5964
casandra.caroccio@jax.ufl.edu
Administrative Manager
Rochelly Ortiz
(904) 244-8846
rochelly.ortiz@jax.ufl.edu

Education

Medical Degree
1997 · Cairo University, Cairo, Egypt
Internal Medicine Residency
2017 · Penn State Milton S. Hershey Medical Center, Hershey, PA, USA
Nephrology Fellowship
2019 · University of Texas Health Science Center, San Antonio, TX, USA