Daniel Soffer, M.D.

Daniel Soffer M.D.

Professor & Medical Director, Endovascular Cardiology; Program Director, Endovascular and Structural Heart Interventions Fellowship

Department: Department of Medicine
Business Phone: (904) 244-3378
Business Email: Daniel.soffer@jax.ufl.edu

Clinical Profile

  • Cardiovascular Disease
  • Interventional Cardiology
  • Clinical Special Interests: Interventional Cardiology; Peripheral and Carotid Interventions, Structural heart; mitral valvuloplasty


P2Y12 Inhibition in Patients Requiring Oral Anticoagulation After Percutaneous Coronary Intervention: The SWAP-AC-2 Study.
JACC. Cardiovascular interventions.17(11):1356-1370[DOI] 10.1016/j.jcin.2024.03.027.[PMID] 38597172.
Switching from Dual Antiplatelet Therapy with Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition with Aspirin Plus Vascular-Dose Rivaroxaban: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC) Study.
Thrombosis and haemostasis.124(3):263-273[DOI] 10.1055/a-2098-6639.[PMID] 37224883.
Cangrelor in Patients With Coronary Artery Disease Pretreated With Ticagrelor: The Switching Antiplatelet (SWAP)-5 Study.
JACC. Cardiovascular interventions.16(1):36-46[DOI] 10.1016/j.jcin.2022.10.034.[PMID] 36317958.
Impact of evolocumab on the pharmacodynamic profiles of clopidogrel in patients with atherosclerotic cardiovascular disease: a randomised, double-blind, placebo-controlled study.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.18(15):1254-1265[DOI] 10.4244/EIJ-D-22-00719.[PMID] 36602868.
Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention: The Switching Antiplatelet-6 (SWAP-6) Study.
JACC. Cardiovascular interventions.16(20):2528-2539[DOI] 10.1016/j.jcin.2023.08.009.[PMID] 37609698.
Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects of ticagrelor in patients with diabetes mellitus and coronary artery disease.
European heart journal. Cardiovascular pharmacotherapy.8(5):452-461[DOI] 10.1093/ehjcvp/pvab042.[PMID] 34114623.
Pharmacodynamic Profiles of Dual-Pathway Inhibition with or without Clopidogrel versus Dual Antiplatelet Therapy in Patients with Atherosclerotic Disease.
Thrombosis and haemostasis.122(8):1341-1351[DOI] 10.1055/a-1730-8725.[PMID] 34983074.
Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet therapy.
European heart journal. Cardiovascular pharmacotherapy.8(7):728-737[DOI] 10.1093/ehjcvp/pvac022.[PMID] 35353154.
Impact of Timing of Pharmacodynamic Assessment on Platelet Reactivity in Patients Treated With Cangrelor.
JACC. Cardiovascular interventions.14(21):2410-2412[DOI] 10.1016/j.jcin.2021.07.051.[PMID] 34736741.
Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.
Thrombosis and haemostasis.120(1):83-93[DOI] 10.1055/s-0039-1695772.[PMID] 31470444.
Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.
Circulation.142(15):1500-1502[DOI] 10.1161/CIRCULATIONAHA.120.048770.[PMID] 33044856.
Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12 Receptor Inhibitors With and Without Aspirin: Results of the VORA-PRATIC Study.
Journal of the American Heart Association.9(8):e015865-[DOI] 10.1161/JAHA.120.015865.[PMID] 32306797.
Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.
JACC. Basic to translational science.5(5):419-428[DOI] 10.1016/j.jacbts.2020.02.009.[PMID] 32478205.
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
JACC. Cardiovascular interventions.12(16):1538-1549[DOI] 10.1016/j.jcin.2019.05.028.[PMID] 31377269.
Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.
JACC. Basic to translational science.4(7):763-775[DOI] 10.1016/j.jacbts.2019.07.011.[PMID] 31998847.
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Circulation.139(14):1661-1670[DOI] 10.1161/CIRCULATIONAHA.118.038317.[PMID] 30630341.
Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.
Circulation.137(23):2450-2462[DOI] 10.1161/CIRCULATIONAHA.118.033983.[PMID] 29526833.
Transcatheter aortic valve-in-valve implantation for early failure of sutureless aortic bioprosthesis.
Journal of cardiac surgery.33(4):172-175[DOI] 10.1111/jocs.13567.[PMID] 29611217.
Pulmonary artery blood flow patterns in fetuses with pulmonary outflow tract obstruction.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.43(3):297-302[DOI] 10.1002/uog.12472.[PMID] 23554091.
Comparative analysis of cerebrovascular resistance in fetuses with single-ventricle congenital heart disease.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.40(1):62-7[DOI] 10.1002/uog.11147.[PMID] 22407644.
Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.
Journal of lipid research.52(2):361-73[DOI] 10.1194/jlr.M011098.[PMID] 21068008.
Images in cardiology: postpartum intramural hematoma-evaluation by computed tomographic angiography.
Journal of clinical hypertension (Greenwich, Conn.).11(11):656-[DOI] 10.1111/j.1751-7176.2009.00173.x.[PMID] 19878377.
Carotid artery stenting in elderly patients: importance of case selection.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.72(3):318-324[DOI] 10.1002/ccd.21620.[PMID] 18726954.
Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4.
Proceedings of the Western Pharmacology Society.51():60-2[DOI] .[PMID] 19544679.
Is there an optimal time for laparoscopic cholecystectomy in acute cholecystitis?
Surgical endoscopy.21(5):805-9[DOI] .[PMID] 17180290.
Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology.26(1):182-8[DOI] .[PMID] 16284192.
Prospective evaluation of aggressive medical therapy for atherosclerotic renal artery stenosis, with renal artery stenting reserved for previously injured heart, brain, or kidney.
The American journal of cardiology.96(9):1322-7[DOI] .[PMID] 16253607.
Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.59(1):21-5[DOI] .[PMID] 12720236.
Suboptimal inhibition of platelet aggregation following tirofiban bolus in patients undergoing percutaneous coronary intervention for unstable angina pectoris.
The American journal of cardiology.91(7):872-5[DOI] .[PMID] 12667576.
Appendicitis in the elderly: what has changed?
The Israel Medical Association journal : IMAJ.2(3):220-3[DOI] .[PMID] 10774271.
Axonal degeneration and regeneration in sensory roots in a genital herpes model.
Acta neuropathologica.77(6):605-11[DOI] .[PMID] 2750478.
A double-label method detects both early (T-antigen) and late (capsid) proteins of JC virus in progressive multifocal leukoencephalopathy brain tissue from AIDS and non-AIDS patients.
Journal of neuroimmunology.19(3):223-36[DOI] .[PMID] 2842376.

Office Information

Academic Office
5th Floor, Ambulatory Care Center
655 West 8th Street, C35
Jacksonville, FL 32209
(904) 244-3378
Medical Secretary
Pamela Cooper
(904) 244-3378
GME Office
5th Floor, Ambulatory Care Center
655 West 8th Street
Jacksonville, FL 32209
GME Program Administrator
Shia Mendoza
(904) 244-4705

Clinical Research


Medical Degree
1993 · Ben-Gurion University of the Negev Medical School for International Health, Beer Sheva, Israel
1995 · Lenox Hill Hospital, New York, NY, USA
Internal Medicine Residency
1997 · Lenox Hill Hospital, New York, NY, USA
Cardiovascular Disease Fellowship
2000 · Lenox Hill Hospital, New York, NY, USA
Interventional Cardiology Fellowship
2002 · William Beaumont Hospital, Royal Oak, MI, USA

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