Daniel Soffer, M.D.

Daniel Soffer M.D.

Associate Professor & Medical Director, Endovascular Cardiology

Department: Department of Medicine
Business Phone: (904) 244-2655
Business Email: Daniel.soffer@jax.ufl.edu

Clinical Profile

Specialties
  • Cardiovascular Disease
  • Interventional Cardiology
Interests
  • Clinical Special Interests: Interventional Cardiology; Peripheral and Carotid Interventions, Structural heart; mitral valvuloplasty

Publications

2022
Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects of ticagrelor in patients with diabetes mellitus and coronary artery disease.
European heart journal. Cardiovascular pharmacotherapy.8(5):452-461[DOI] 10.1093/ehjcvp/pvab042.[PMID] 34114623.
2022
Pharmacodynamic Profiles of Dual-Pathway Inhibition with or without Clopidogrel versus Dual Antiplatelet Therapy in Patients with Atherosclerotic Disease.
Thrombosis and haemostasis.122(8):1341-1351[DOI] 10.1055/a-1730-8725.[PMID] 34983074.
2022
Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet therapy.
European heart journal. Cardiovascular pharmacotherapy.8(7):728-737[DOI] 10.1093/ehjcvp/pvac022.[PMID] 35353154.
2021
Impact of Timing of Pharmacodynamic Assessment on Platelet Reactivity in Patients Treated With Cangrelor.
JACC. Cardiovascular interventions.14(21):2410-2412[DOI] 10.1016/j.jcin.2021.07.051.[PMID] 34736741.
2020
Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.
Thrombosis and haemostasis.120(1):83-93[DOI] 10.1055/s-0039-1695772.[PMID] 31470444.
2020
Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.
Circulation.142(15):1500-1502[DOI] 10.1161/CIRCULATIONAHA.120.048770.[PMID] 33044856.
2020
Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12 Receptor Inhibitors With and Without Aspirin: Results of the VORA-PRATIC Study.
Journal of the American Heart Association.9(8):e015865-[DOI] 10.1161/JAHA.120.015865.[PMID] 32306797.
2020
Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.
JACC. Basic to translational science.5(5):419-428[DOI] 10.1016/j.jacbts.2020.02.009.[PMID] 32478205.
2019
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
JACC. Cardiovascular interventions.12(16):1538-1549[DOI] 10.1016/j.jcin.2019.05.028.[PMID] 31377269.
2019
Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.
JACC. Basic to translational science.4(7):763-775[DOI] 10.1016/j.jacbts.2019.07.011.[PMID] 31998847.
2019
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Circulation.139(14):1661-1670[DOI] 10.1161/CIRCULATIONAHA.118.038317.[PMID] 30630341.
2018
Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.
Circulation.137(23):2450-2462[DOI] 10.1161/CIRCULATIONAHA.118.033983.[PMID] 29526833.
2018
Transcatheter aortic valve-in-valve implantation for early failure of sutureless aortic bioprosthesis.
Journal of cardiac surgery.33(4):172-175[DOI] 10.1111/jocs.13567.[PMID] 29611217.
2014
Pulmonary artery blood flow patterns in fetuses with pulmonary outflow tract obstruction.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.43(3):297-302[DOI] 10.1002/uog.12472.[PMID] 23554091.
2012
Comparative analysis of cerebrovascular resistance in fetuses with single-ventricle congenital heart disease.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.40(1):62-7[DOI] 10.1002/uog.11147.[PMID] 22407644.
2011
Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.
Journal of lipid research.52(2):361-73[DOI] 10.1194/jlr.M011098.[PMID] 21068008.
2009
Images in cardiology: postpartum intramural hematoma-evaluation by computed tomographic angiography.
Journal of clinical hypertension (Greenwich, Conn.).11(11):656-[DOI] 10.1111/j.1751-7176.2009.00173.x.[PMID] 19878377.
2008
Carotid artery stenting in elderly patients: importance of case selection.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.72(3):318-324[DOI] 10.1002/ccd.21620.[PMID] 18726954.
2008
Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4.
Proceedings of the Western Pharmacology Society.51():60-2[DOI] .[PMID] 19544679.
2007
Is there an optimal time for laparoscopic cholecystectomy in acute cholecystitis?
Surgical endoscopy.21(5):805-9[DOI] .[PMID] 17180290.
2006
Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome.
Arteriosclerosis, thrombosis, and vascular biology.26(1):182-8[DOI] .[PMID] 16284192.
2005
Prospective evaluation of aggressive medical therapy for atherosclerotic renal artery stenosis, with renal artery stenting reserved for previously injured heart, brain, or kidney.
The American journal of cardiology.96(9):1322-7[DOI] .[PMID] 16253607.
2003
Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.59(1):21-5[DOI] .[PMID] 12720236.
2003
Suboptimal inhibition of platelet aggregation following tirofiban bolus in patients undergoing percutaneous coronary intervention for unstable angina pectoris.
The American journal of cardiology.91(7):872-5[DOI] .[PMID] 12667576.
1989
Axonal degeneration and regeneration in sensory roots in a genital herpes model.
Acta neuropathologica.77(6):605-11[DOI] .[PMID] 2750478.
1988
A double-label method detects both early (T-antigen) and late (capsid) proteins of JC virus in progressive multifocal leukoencephalopathy brain tissue from AIDS and non-AIDS patients.
Journal of neuroimmunology.19(3):223-36[DOI] .[PMID] 2842376.

Office Information

Academic Office
5th Floor, Ambulatory Care Center
655 West 8th Street, C35
Jacksonville, FL 32209
(904) 244-2656
Daniel.soffer@jax.ufl.edu
Administrative Manager
Erika Jackson
(904) 244-2655
erika.jackson@jax.ufl.edu

Education

Medical Degree
1993 · Ben-Gurion University of the Negev Medical School for International Health, Beer Sheva, Israel
Internship
1995 · Lenox Hill Hospital, New York, NY, USA
Internal Medicine Residency
1997 · Lenox Hill Hospital, New York, NY, USA
Cardiovascular Disease Fellowship
2000 · Lenox Hill Hospital, New York, NY, USA
Interventional Cardiology Fellowship
2002 · William Beaumont Hospital, Royal Oak, MI, USA

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