Daniel Soffer M.D.

Professor & Medical Director, Endovascular Cardiology; Program Director, Endovascular and Structural Heart Interventions Fellowship

Department: Department of Medicine

Business Phone: (904) 244-3378

Business Email: Daniel.soffer@jax.ufl.edu

Appointments and Locations

Clinical Profile

Specialties

Cardiovascular Disease
Interventional Cardiology

Interests

Clinical Special Interests: Interventional Cardiology; Peripheral and Carotid Interventions, Structural heart; mitral valvuloplasty

Publications

2024

Clopidogrel-Mediated P2Y12 Inhibition According to Renal Function in Patients With Diabetes Mellitus and CAD.

JACC. Basic to translational science.9(7):865-876[DOI] 10.1016/j.jacbts.2024.03.003.[PMID] 39170956.

1 citations·PubMed·Publisher's Site

2024

P2Y12 Inhibition in Patients Requiring Oral Anticoagulation After Percutaneous Coronary Intervention: The SWAP-AC-2 Study.

JACC. Cardiovascular interventions.17(11):1356-1370[DOI] 10.1016/j.jcin.2024.03.027.[PMID] 38597172.

6 citations·PubMed·Publisher's Site

2024

Switching from Dual Antiplatelet Therapy with Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition with Aspirin Plus Vascular-Dose Rivaroxaban: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC) Study.

Thrombosis and haemostasis.124(3):263-273[DOI] 10.1055/a-2098-6639.[PMID] 37224883.

6 citations·PubMed·Publisher's Site

2023

Cangrelor in Patients With Coronary Artery Disease Pretreated With Ticagrelor: The Switching Antiplatelet (SWAP)-5 Study.

JACC. Cardiovascular interventions.16(1):36-46[DOI] 10.1016/j.jcin.2022.10.034.[PMID] 36317958.

18 citations·PubMed·Publisher's Site

2023

Impact of evolocumab on the pharmacodynamic profiles of clopidogrel in patients with atherosclerotic cardiovascular disease: a randomised, double-blind, placebo-controlled study.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.18(15):1254-1265[DOI] 10.4244/EIJ-D-22-00719.[PMID] 36602868.

12 citations·PubMed·Publisher's Site

2023

Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention: The Switching Antiplatelet-6 (SWAP-6) Study.

JACC. Cardiovascular interventions.16(20):2528-2539[DOI] 10.1016/j.jcin.2023.08.009.[PMID] 37609698.

9 citations·PubMed·Publisher's Site

2022

Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects of ticagrelor in patients with diabetes mellitus and coronary artery disease.

European heart journal. Cardiovascular pharmacotherapy.8(5):452-461[DOI] 10.1093/ehjcvp/pvab042.[PMID] 34114623.

2 citations·PubMed·Publisher's Site

2022

Pharmacodynamic Profiles of Dual-Pathway Inhibition with or without Clopidogrel versus Dual Antiplatelet Therapy in Patients with Atherosclerotic Disease.

Thrombosis and haemostasis.122(8):1341-1351[DOI] 10.1055/a-1730-8725.[PMID] 34983074.

18 citations·PubMed·Publisher's Site

2022

Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet therapy.

European heart journal. Cardiovascular pharmacotherapy.8(7):728-737[DOI] 10.1093/ehjcvp/pvac022.[PMID] 35353154.

18 citations·PubMed·Publisher's Site

2021

Impact of Timing of Pharmacodynamic Assessment on Platelet Reactivity in Patients Treated With Cangrelor.

JACC. Cardiovascular interventions.14(21):2410-2412[DOI] 10.1016/j.jcin.2021.07.051.[PMID] 34736741.

4 citations·PubMed·Publisher's Site

2020

Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.

Thrombosis and haemostasis.120(1):83-93[DOI] 10.1055/s-0039-1695772.[PMID] 31470444.

18 citations·PubMed·Publisher's Site

2020

Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.

Circulation.142(15):1500-1502[DOI] 10.1161/CIRCULATIONAHA.120.048770.[PMID] 33044856.

10 citations·PubMed·Publisher's Site

2020

Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12 Receptor Inhibitors With and Without Aspirin: Results of the VORA-PRATIC Study.

Journal of the American Heart Association.9(8):e015865-[DOI] 10.1161/JAHA.120.015865.[PMID] 32306797.

18 citations·PubMed·Publisher's Site

2020

Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.

JACC. Basic to translational science.5(5):419-428[DOI] 10.1016/j.jacbts.2020.02.009.[PMID] 32478205.

27 citations·PubMed·Publisher's Site

2019

Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.

JACC. Cardiovascular interventions.12(16):1538-1549[DOI] 10.1016/j.jcin.2019.05.028.[PMID] 31377269.

29 citations·PubMed·Publisher's Site

2019

Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.

JACC. Basic to translational science.4(7):763-775[DOI] 10.1016/j.jacbts.2019.07.011.[PMID] 31998847.

15 citations·PubMed·Publisher's Site

2019

Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.

Circulation.139(14):1661-1670[DOI] 10.1161/CIRCULATIONAHA.118.038317.[PMID] 30630341.

118 citations·PubMed·Publisher's Site

2018

Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.

Circulation.137(23):2450-2462[DOI] 10.1161/CIRCULATIONAHA.118.033983.[PMID] 29526833.

46 citations·PubMed·Publisher's Site

2018

Transcatheter aortic valve-in-valve implantation for early failure of sutureless aortic bioprosthesis.

Journal of cardiac surgery.33(4):172-175[DOI] 10.1111/jocs.13567.[PMID] 29611217.

11 citations·PubMed·Publisher's Site

2014

Pulmonary artery blood flow patterns in fetuses with pulmonary outflow tract obstruction.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.43(3):297-302[DOI] 10.1002/uog.12472.[PMID] 23554091.

9 citations·PubMed·Publisher's Site

2012

Comparative analysis of cerebrovascular resistance in fetuses with single-ventricle congenital heart disease.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.40(1):62-7[DOI] 10.1002/uog.11147.[PMID] 22407644.

46 citations·PubMed·Publisher's Site

2011

Doppler ultrasound for the assessment of conservatively treated blunt splenic injuries: a prospective study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society.37(2):197-202[DOI] 10.1007/s00068-010-0044-7.[PMID] 26814956.

3 citations·PubMed·Publisher's Site

2011

Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function.

Journal of lipid research.52(2):361-73[DOI] 10.1194/jlr.M011098.[PMID] 21068008.

125 citations·PubMed·Publisher's Site

2009

Images in cardiology: postpartum intramural hematoma-evaluation by computed tomographic angiography.

Journal of clinical hypertension (Greenwich, Conn.).11(11):656-[DOI] 10.1111/j.1751-7176.2009.00173.x.[PMID] 19878377.

2 citations·PubMed·Publisher's Site

2008

Carotid artery stenting in elderly patients: importance of case selection.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.72(3):318-324[DOI] 10.1002/ccd.21620.[PMID] 18726954.

49 citations·PubMed·Publisher's Site

2008

Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4.

Proceedings of the Western Pharmacology Society.51():60-2[DOI] .[PMID] 19544679.

1 citations·PubMed·Publisher's Site

2007

Is there an optimal time for laparoscopic cholecystectomy in acute cholecystitis?

Surgical endoscopy.21(5):805-9[DOI] .[PMID] 17180290.

28 citations·PubMed·Publisher's Site

2006

Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome.

Arteriosclerosis, thrombosis, and vascular biology.26(1):182-8[DOI] .[PMID] 16284192.

129 citations·PubMed·Publisher's Site

2005

Prospective evaluation of aggressive medical therapy for atherosclerotic renal artery stenosis, with renal artery stenting reserved for previously injured heart, brain, or kidney.

The American journal of cardiology.96(9):1322-7[DOI] .[PMID] 16253607.

18 citations·PubMed·Publisher's Site

2003

Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.59(1):21-5[DOI] .[PMID] 12720236.

80 citations·PubMed·Publisher's Site

2003

Suboptimal inhibition of platelet aggregation following tirofiban bolus in patients undergoing percutaneous coronary intervention for unstable angina pectoris.

The American journal of cardiology.91(7):872-5[DOI] .[PMID] 12667576.

13 citations·PubMed·Publisher's Site

2000

Appendicitis in the elderly: what has changed?

The Israel Medical Association journal : IMAJ.2(3):220-3[DOI] .[PMID] 10774271.

12 citations·PubMed·Publisher's Site

1989

Axonal degeneration and regeneration in sensory roots in a genital herpes model.

Acta neuropathologica.77(6):605-11[DOI] .[PMID] 2750478.

8 citations·PubMed·Publisher's Site

1988

A double-label method detects both early (T-antigen) and late (capsid) proteins of JC virus in progressive multifocal leukoencephalopathy brain tissue from AIDS and non-AIDS patients.

Journal of neuroimmunology.19(3):223-36[DOI] .[PMID] 2842376.

21 citations·PubMed·Publisher's Site