Francesco Franchi, M.B.Ch.B. (M.D.)

Francesco Franchi M.B.Ch.B. (M.D.)

Associate Professor

Department: Department of Medicine
Business Phone: (904) 244-2060
Business Email: francesco.franchi@jax.ufl.edu
Appointments and Locations

Clinical Profile

Specialties
  • Cardiovascular Disease
Languages
  • Speaks English and Italian

Publications

2023
Cangrelor in Patients With Coronary Artery Disease Pretreated With Ticagrelor
JACC: Cardiovascular Interventions.16(1):36-46[DOI] 10.1016/j.jcin.2022.10.034.[PMID] .
PubMed·Publisher's Site
2023
Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab.
Clinical pharmacokinetics.62(5):673-692[DOI] 10.1007/s40262-023-01245-3.[PMID] 37118383.
PubMed·Publisher's Site
2023
Defining Strategies of Modulation of Antiplatelet Therapy in Patients With Coronary Artery Disease: A Consensus Document from the Academic Research Consortium.
Circulation.147(25):1933-1944[DOI] 10.1161/CIRCULATIONAHA.123.064473.[PMID] 37335828.
2 citations·PubMed·Publisher's Site
2023
Dual pathway inhibition in atherothrombosis prevention: yes, now we can!
Minerva cardiology and angiology.71(4):363-373[DOI] 10.23736/S2724-5683.21.05867-1.[PMID] 34761666.
1 citations·PubMed·Publisher's Site
2023
Dual pathway inhibition in patients with atherosclerotic disease: pharmacodynamic considerations and clinical implications.
Expert review of clinical pharmacology.16(1):27-38[DOI] 10.1080/17512433.2023.2154651.[PMID] 36455906.
1 citations·PubMed·Publisher's Site
2023
Evaluation of Potential Racial Disparities in CYP2C19-Guided P2Y12 Inhibitor Prescribing After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.113(3):615-623[DOI] 10.1002/cpt.2776.[PMID] 36306392.
2 citations·PubMed·Publisher's Site
2023
Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis.
Thrombosis and haemostasis.123(6):576-584[DOI] 10.1055/a-2043-0346.[PMID] 36841245.
1 citations·PubMed·Publisher's Site
2023
Genotype-Guided Selection of Antiplatelet Therapy
JACC: Cardiovascular Interventions.16(7):844-846[DOI] 10.1016/j.jcin.2023.02.021.[PMID] .
PubMed·Publisher's Site
2023
Impact of evolocumab on the pharmacodynamic profiles of clopidogrel in patients with atherosclerotic cardiovascular disease: a randomised, double-blind, placebo-controlled study.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.18(15):1254-1265[DOI] 10.4244/EIJ-D-22-00719.[PMID] 36602868.
2 citations·PubMed·Publisher's Site
2023
Influence of body weight and body mass index on the chronic pharmacokinetic and pharmacodynamic responses to clinically available doses of ticagrelor in patients with chronic coronary syndromes.
Vascular pharmacology.149():107145-[DOI] 10.1016/j.vph.2023.107145.[PMID] 36720377.
PubMed·Publisher's Site
2023
Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial.
Arteriosclerosis, thrombosis, and vascular biology.43(8):1572-1582[DOI] 10.1161/ATVBAHA.122.318748.[PMID] 37381988.
PubMed·Publisher's Site
2023
Role of platelet function and genetic testing in patients undergoing percutaneous coronary intervention.
Trends in cardiovascular medicine.33(3):133-138[DOI] 10.1016/j.tcm.2021.12.007.[PMID] 34936903.
11 citations·PubMed·Publisher's Site
2023
Switching From Cangrelor to Prasugrel in Patients Undergoing Percutaneous Coronary Intervention
JACC: Cardiovascular Interventions.():-[DOI] 10.1016/j.jcin.2023.08.009.[PMID] .
PubMed·Publisher's Site
2023
Switching from Dual Antiplatelet Therapy with Aspirin Plus a P2Y12 Inhibitor to Dual Pathway Inhibition with Aspirin Plus Vascular-Dose Rivaroxaban: The Switching Anti-Platelet and Anti-Coagulant Therapy (SWAP-AC) Study.
Thrombosis and haemostasis.():-[DOI] 10.1055/a-2098-6639.[PMID] 37224883.
PubMed·Publisher's Site
2022
Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials.
European heart journal.43(10):959-967[DOI] 10.1093/eurheartj/ehab836.[PMID] 34918066.
54 citations·PubMed·Publisher's Site
2022
CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings.
Journal of the American Heart Association.11(4):e024159-[DOI] 10.1161/JAHA.121.024159.[PMID] 35156424.
14 citations·PubMed·Publisher's Site
2022
Impact of chronic kidney disease on the pharmacodynamic and pharmacokinetic effects of ticagrelor in patients with diabetes mellitus and coronary artery disease.
European heart journal. Cardiovascular pharmacotherapy.8(5):452-461[DOI] 10.1093/ehjcvp/pvab042.[PMID] 34114623.
2 citations·PubMed·Publisher's Site
2022
Impact of diabetes mellitus on the pharmacodynamic effects of prasugrel and ticagrelor after switching from clopidogrel in patients with coronary artery disease
Journal of Thrombosis and Thrombolysis.54(3):461-469[DOI] 10.1007/s11239-022-02696-4.[PMID] .
PubMed·Publisher's Site
2022
Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation.
Clinical pharmacology and therapeutics.112(1):146-155[DOI] 10.1002/cpt.2612.[PMID] 35429163.
4 citations·PubMed·Publisher's Site
2022
P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention.
Nature reviews. Cardiology.19(12):829-844[DOI] 10.1038/s41569-022-00725-6.[PMID] 35697777.
20 citations·PubMed·Publisher's Site
2022
Patterns and Outcomes of Dual Antiplatelet Therapy Discontinuation After Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.15(8):807-809[DOI] 10.1016/j.jcin.2022.02.048.[PMID] 35450680.
1 citations·PubMed·Publisher's Site
2022
Pharmacodynamic Profiles of Dual-Pathway Inhibition with or without Clopidogrel versus Dual Antiplatelet Therapy in Patients with Atherosclerotic Disease.
Thrombosis and haemostasis.122(8):1341-1351[DOI] 10.1055/a-1730-8725.[PMID] 34983074.
3 citations·PubMed·Publisher's Site
2022
Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study.
Journal of thrombosis and thrombolysis.54(3):373-381[DOI] 10.1007/s11239-022-02687-5.[PMID] 36036856.
3 citations·PubMed·Publisher's Site
2022
Platelet P2Y12 inhibiting therapy in adjunct to vascular dose of rivaroxaban or aspirin: a pharmacodynamic study of dual pathway inhibition vs. dual antiplatelet therapy.
European heart journal. Cardiovascular pharmacotherapy.8(7):728-737[DOI] 10.1093/ehjcvp/pvac022.[PMID] 35353154.
3 citations·PubMed·Publisher's Site
2022
Precision medicine in interventional cardiology: implications for antiplatelet therapy in patients undergoing percutaneous coronary intervention.
Pharmacogenomics.23(13):723-737[DOI] 10.2217/pgs-2022-0057.[PMID] 35938534.
14 citations·PubMed·Publisher's Site
2022
Reply: The Effects of Cangrelor on Platelet Aggregation in STEMI Patients: Methodological or Pharmacological Issues?
JACC. Cardiovascular interventions.15(2):230-231[DOI] 10.1016/j.jcin.2021.12.002.[PMID] 35057998.
PubMed·Publisher's Site
2022
Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
European heart journal. Cardiovascular pharmacotherapy.8(7):677-686[DOI] 10.1093/ehjcvp/pvab070.[PMID] 34519777.
44 citations·PubMed·Publisher's Site
2021
Effects of D-allulose on glucose tolerance and insulin response to a standard oral sucrose load: results of a prospective, randomized, crossover study
BMJ Open Diabetes Research & Care.9(1):e001939-[DOI] 10.1136/bmjdrc-2020-001939.[PMID] 33637605.
8 citations·PubMed·Publisher's Site
2021
Genetic testing in patients undergoing percutaneous coronary intervention: rationale, evidence and practical recommendations.
Expert review of clinical pharmacology.14(8):963-978[DOI] 10.1080/17512433.2021.1927709.[PMID] 33993817.
22 citations·PubMed·Publisher's Site
2021
Genotype-Guided Antiplatelet Therapy in Patients With Coronary Artery Disease.
JACC. Cardiovascular interventions.14(7):751-753[DOI] 10.1016/j.jcin.2021.02.005.[PMID] 33744206.
2 citations·PubMed·Publisher's Site
2021
Guided selection of antiplatelet therapy in acute coronary syndrome: Impact on outcomes and resource utilization.
International journal of cardiology.345():36-38[DOI] 10.1016/j.ijcard.2021.10.010.[PMID] 34678324.
7 citations·PubMed·Publisher's Site
2021
Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Lancet (London, England).397(10283):1470-1483[DOI] 10.1016/S0140-6736(21)00533-X.[PMID] 33865495.
102 citations·PubMed·Publisher's Site
2021
Impact of the CYP2C19*17 Allele on Outcomes in Patients Receiving Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.
Clinical pharmacology and therapeutics.109(3):705-715[DOI] 10.1002/cpt.2039.[PMID] 32897581.
19 citations·PubMed·Publisher's Site
2021
Impact of Timing of Pharmacodynamic Assessment on Platelet Reactivity in Patients Treated With Cangrelor.
JACC. Cardiovascular interventions.14(21):2410-2412[DOI] 10.1016/j.jcin.2021.07.051.[PMID] 34736741.
2 citations·PubMed·Publisher's Site
2021
Typical atrial flutter from blunt cardiac injury: an atypical cause.
Journal of geriatric cardiology : JGC.18(2):155-157[DOI] 10.11909/j.issn.1671-5411.2021.02.009.[PMID] 33747066.
PubMed·Publisher's Site
2021
Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor
Journal of Thrombosis and Thrombolysis.51(3):741-747[DOI] 10.1007/s11239-021-02386-7.[PMID] 33582955.
5 citations·PubMed·Publisher's Site
2020
Clinical Utility of Pharmacogene Panel-Based Testing in Patients Undergoing Percutaneous Coronary Intervention.
Clinical and translational science.13(3):473-481[DOI] 10.1111/cts.12729.[PMID] 31758664.
8 citations·PubMed·Publisher's Site
2020
Clopidogrel drug interactions: a review of the evidence and clinical implications.
Expert opinion on drug metabolism & toxicology.16(11):1079-1096[DOI] 10.1080/17425255.2020.1814254.[PMID] 32835535.
4 citations·PubMed·Publisher's Site
2020
Correction: Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.22(11):1919-[DOI] 10.1038/s41436-020-0931-1.[PMID] 32747766.
PubMed·Publisher's Site
2020
Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network.
Pharmacogenomics and personalized medicine.13():217-226[DOI] 10.2147/PGPM.S241599.[PMID] 32765043.
10 citations·PubMed·Publisher's Site
2020
Effects of Edoxaban on the Cellular and Protein Phase of Coagulation in Patients with Coronary Artery Disease on Dual Antiplatelet Therapy with Aspirin and Clopidogrel: Results of the EDOX-APT Study.
Thrombosis and haemostasis.120(1):83-93[DOI] 10.1055/s-0039-1695772.[PMID] 31470444.
18 citations·PubMed·Publisher's Site
2020
Evaluating the extent of reusability of CYP2C19 genotype data among patients genotyped for antiplatelet therapy selection.
Genetics in medicine : official journal of the American College of Medical Genetics.22(11):1898-1902[DOI] 10.1038/s41436-020-0894-2.[PMID] 32678355.
5 citations·PubMed·Publisher's Site
2020
Pharmacodynamic and Pharmacokinetic Effects of a Low Maintenance Dose Ticagrelor Regimen Versus Standard Dose Clopidogrel in Diabetes Mellitus Patients Without Previous Major Cardiovascular Events Undergoing Elective Percutaneous Coronary Intervention: The OPTIMUS-6 Study.
Circulation.142(15):1500-1502[DOI] 10.1161/CIRCULATIONAHA.120.048770.[PMID] 33044856.
10 citations·PubMed·Publisher's Site
2020
Pharmacodynamic Effects of Vorapaxar in Prior Myocardial Infarction Patients Treated With Potent Oral P2Y12 Receptor Inhibitors With and Without Aspirin: Results of the VORA-PRATIC Study.
Journal of the American Heart Association.9(8):e015865-[DOI] 10.1161/JAHA.120.015865.[PMID] 32306797.
17 citations·PubMed·Publisher's Site
2020
Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes: Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing.
JACC. Basic to translational science.5(5):419-428[DOI] 10.1016/j.jacbts.2020.02.009.[PMID] 32478205.
18 citations·PubMed·Publisher's Site
2019
Effects of Methylnaltrexone on Ticagrelor-Induced Antiplatelet Effects in Coronary Artery Disease Patients Treated With Morphine.
JACC. Cardiovascular interventions.12(16):1538-1549[DOI] 10.1016/j.jcin.2019.05.028.[PMID] 31377269.
23 citations·PubMed·Publisher's Site
2019
Impact of Diabetes Mellitus and Chronic Kidney Disease on Cardiovascular Outcomes and Platelet P2Y12 Receptor Antagonist Effects in Patients With Acute Coronary Syndromes: Insights From the PLATO Trial.
Journal of the American Heart Association.8(6):e011139-[DOI] 10.1161/JAHA.118.011139.[PMID] 30857464.
27 citations·PubMed·Publisher's Site
2019
Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus: Results of the OPTIMUS-5 Study.
JACC. Basic to translational science.4(7):763-775[DOI] 10.1016/j.jacbts.2019.07.011.[PMID] 31998847.
12 citations·PubMed·Publisher's Site
2019
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
Circulation.139(14):1661-1670[DOI] 10.1161/CIRCULATIONAHA.118.038317.[PMID] 30630341.
87 citations·PubMed·Publisher's Site
2019
Role of oral anticoagulant therapy for secondary prevention in patients with stable atherothrombotic disease manifestations.
Therapeutic advances in hematology.10():2040620719861475-[DOI] 10.1177/2040620719861475.[PMID] 31321012.
3 citations·PubMed·Publisher's Site
2019
Switching Oral Anticoagulant Therapy in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.12(23):2342-2345[DOI] 10.1016/j.jcin.2019.10.017.[PMID] 31806215.
1 citations·PubMed·Publisher's Site
2019
Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.12(16):1521-1537[DOI] 10.1016/j.jcin.2019.03.034.[PMID] 31202949.
309 citations·PubMed·Publisher's Site
2018
Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention.
Nature reviews. Cardiology.15(8):480-496[DOI] 10.1038/s41569-018-0049-1.[PMID] 29973709.
160 citations·PubMed·Publisher's Site
2018
Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention.
Journal of translational medicine.16(1):92-[DOI] 10.1186/s12967-018-1469-8.[PMID] 29642909.
35 citations·PubMed·Publisher's Site
2018
Diabetes and antiplatelet therapy: from bench to bedside.
Cardiovascular diagnosis and therapy.8(5):594-609[DOI] 10.21037/cdt.2018.05.09.[PMID] 30498684.
39 citations·PubMed·Publisher's Site
2018
Evolution of Coronary Stent Technology and Implications for Duration of Dual Antiplatelet Therapy.
Progress in cardiovascular diseases.60(4-5):478-490[DOI] 10.1016/j.pcad.2017.12.004.[PMID] 29291426.
48 citations·PubMed·Publisher's Site
2018
Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy.
Clinical pharmacology and therapeutics.104(4):664-674[DOI] 10.1002/cpt.1006.[PMID] 29280137.
79 citations·PubMed·Publisher's Site
2018
Pharmacodynamic Effects of Switching From Ticagrelor to Clopidogrel in Patients With Coronary Artery Disease: Results of the SWAP-4 Study.
Circulation.137(23):2450-2462[DOI] 10.1161/CIRCULATIONAHA.118.033983.[PMID] 29526833.
43 citations·PubMed·Publisher's Site
2018
Role for Thrombin Receptor Antagonism With Vorapaxar in Secondary Prevention of Atherothrombotic Events: From Bench to Bedside.
Journal of cardiovascular pharmacology and therapeutics.23(1):23-37[DOI] 10.1177/1074248417708617.[PMID] 28565918.
15 citations·PubMed·Publisher's Site
2018
Role of genetic testing in patients undergoing percutaneous coronary intervention.
Expert review of clinical pharmacology.11(2):151-164[DOI] 10.1080/17512433.2017.1353909.[PMID] 28689434.
50 citations·PubMed·Publisher's Site
2018
Standard- and Low-Dose Ticagrelor After Percutaneous Coronary Intervention: Finding the Balance for Patients With Stable Coronary Artery Disease.
Circulation.138(13):1301-1303[DOI] 10.1161/CIRCULATIONAHA.118.036240.[PMID] 30354428.
0 citations·PubMed·Publisher's Site
2018
The quest for safer antithrombotic treatment regimens in patients with coronary artery disease: new strategies and paradigm shifts.
Expert review of hematology.11(1):5-12[DOI] 10.1080/17474086.2018.1400378.[PMID] 29091481.
17 citations·PubMed·Publisher's Site
2018
The Quest for the Optimal Periprocedural Antithrombotic Treatment Strategy in ACS Patients Undergoing PCI.
Journal of the American College of Cardiology.71(11):1243-1245[DOI] 10.1016/j.jacc.2018.01.040.[PMID] 29544608.
4 citations·PubMed·Publisher's Site
2017
Antithrombotic therapy for patients with STEMI undergoing primary PCI.
Nature reviews. Cardiology.14(6):361-379[DOI] 10.1038/nrcardio.2017.18.[PMID] 28230176.
70 citations·PubMed·Publisher's Site
2017
Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status.
Thrombosis and haemostasis.117(5):940-947[DOI] 10.1160/TH16-09-0703.[PMID] 28300867.
18 citations·PubMed·Publisher's Site
2017
Crushed ticagrelor in comatose patients treated with primary percutaneous coronary intervention.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.12(14):1681-1683[DOI] 10.4244/EIJV12I14A276.[PMID] 28216470.
2 citations·PubMed·Publisher's Site
2017
De-Escalation of Platelet P2Y12 Receptor Inhibiting Therapy After Percutaneous Coronary Intervention: Does One Size Fit All?
JACC. Cardiovascular interventions.10(24):2571-2573[DOI] 10.1016/j.jcin.2017.10.007.[PMID] 29268887.
4 citations·PubMed·Publisher's Site
2017
Drug-Drug Interactions When Switching Between Intravenous and Oral P2Y12 Receptor Inhibitors: How Real Is It?
JACC. Cardiovascular interventions.10(2):130-132[DOI] 10.1016/j.jcin.2016.11.021.[PMID] 28104205.
4 citations·PubMed·Publisher's Site
2017
Impact of chronic kidney disease on platelet P2Y12 receptor signalling in patients with type 2 diabetes mellitus.
Thrombosis and haemostasis.117(1):201-203[DOI] 10.1160/TH16-08-0594.[PMID] 27786340.
6 citations·PubMed·Publisher's Site
2017
Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention.
Journal of the American Heart Association.6(4):-[DOI] 10.1161/JAHA.117.005650.[PMID] 28356282.
30 citations·PubMed·Publisher's Site
2017
Institutional profile: University of Florida Health Personalized Medicine Program.
Pharmacogenomics.18(5):421-426[DOI] 10.2217/pgs-2017-0028.[PMID] 28346068.
49 citations·PubMed·Publisher's Site
2017
International Expert Consensus on Switching Platelet P2Y12 Receptor-Inhibiting Therapies.
Circulation.136(20):1955-1975[DOI] 10.1161/CIRCULATIONAHA.117.031164.[PMID] 29084738.
237 citations·PubMed·Publisher's Site
2017
In Vitro Pharmacodynamic Effects of Cangrelor on Platelet P2Y12 Receptor-Mediated Signaling in Ticagrelor-Treated Patients.
JACC. Cardiovascular interventions.10(13):1374-1375[DOI] 10.1016/j.jcin.2017.04.027.[PMID] 28683943.
8 citations·PubMed·Publisher's Site
2017
Oral trans-mucosal administration of ticagrelor: is this really the future?
Thrombosis and haemostasis.117(5):826-828[DOI] 10.1160/TH17-03-0177.[PMID] 28331923.
PubMed·Publisher's Site
2017
Reply: Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study.
Journal of the American College of Cardiology.69(2):250-251[DOI] 10.1016/j.jacc.2016.09.982.[PMID] 28081837.
PubMed·Publisher's Site
2017
Switching from ticagrelor to clopidogrel: New answers and further questions.
Thrombosis and haemostasis.117(2):207-208[DOI] 10.1160/TH16-12-0909.[PMID] 28004060.
3 citations·PubMed·Publisher's Site
2017
Switching P2Y12 Receptor Inhibiting Therapies.
Interventional cardiology clinics.6(1):67-89[DOI] 10.1016/j.iccl.2016.08.006.[PMID] 27886824.
6 citations·PubMed·Publisher's Site
2017
The role of oral anticoagulant therapy in patients with acute coronary syndrome.
Therapeutic advances in hematology.8(12):353-366[DOI] 10.1177/2040620717733691.[PMID] 29204262.
15 citations·PubMed·Publisher's Site
2016
A head-to-head pharmacodynamic comparison of prasugrel vs. ticagrelor after switching from clopidogrel in patients with coronary artery disease: results of a prospective randomized study.
European heart journal.37(35):2722-30[DOI] 10.1093/eurheartj/ehv744.[PMID] 26848148.
49 citations·PubMed·Publisher's Site
2016
A Safety Evaluation of Cangrelor in Patients Undergoing PCI.
Expert opinion on drug safety.15(2):275-85[DOI] 10.1517/14740338.2016.1133585.[PMID] 26680584.
12 citations·PubMed·Publisher's Site
2016
Antithrombotic Therapy for Secondary Prevention in Patients With Diabetes Mellitus and Coronary Artery Disease.
Circulation journal : official journal of the Japanese Circulation Society.80(4):791-801[DOI] 10.1253/circj.CJ-16-0208.[PMID] 26984587.
16 citations·PubMed·Publisher's Site
2016
Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study.
Journal of the American College of Cardiology.67(17):1994-2004[DOI] 10.1016/j.jacc.2016.02.045.[PMID] 27012781.
91 citations·PubMed·Publisher's Site
2016
Defining a Role for Prasugrel in Patients With Stable Coronary Artery Disease Undergoing Ad Hoc Percutaneous Coronary Intervention.
JACC. Cardiovascular interventions.9(3):228-230[DOI] 10.1016/j.jcin.2015.11.022.[PMID] 26777325.
PubMed·Publisher's Site
2016
Dual antiplatelet therapy after coronary stenting.
Expert opinion on pharmacotherapy.17(13):1775-87[DOI] 10.1080/14656566.2016.1202924.[PMID] 27309035.
9 citations·PubMed·Publisher's Site
2016
Effects of dabigatran on the cellular and protein phase of coagulation in patients with coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. Results from a prospective, randomised, double-blind, placebo-controlled study.
Thrombosis and haemostasis.115(3):622-31[DOI] 10.1160/TH15-06-0467.[PMID] 26633836.
21 citations·PubMed·Publisher's Site
2016
Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Patients With Low-Risk ACS Undergoing Ad Hoc PCI.
Journal of the American College of Cardiology.67(6):603-613[DOI] 10.1016/j.jacc.2015.11.044.[PMID] 26868683.
35 citations·PubMed·Publisher's Site
2016
Impact of timing from blood sampling to pharmacodynamic assessment on measures of platelet reactivity in patients treated with P2Y12 receptor inhibitors.
Thrombosis and haemostasis.116(6):1060-1069[DOI] .[PMID] 27488362.
7 citations·PubMed·Publisher's Site
2016
Pharmacodynamic Comparison of Prasugrel Versus Ticagrelor in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 Study.
Circulation.134(11):780-92[DOI] 10.1161/CIRCULATIONAHA.116.023402.[PMID] 27559041.
74 citations·PubMed·Publisher's Site
2016
Pharmacodynamic Effects of Switching From Prasugrel to Ticagrelor: Results of the Prospective, Randomized SWAP-3 Study.
JACC. Cardiovascular interventions.9(11):1089-98[DOI] 10.1016/j.jcin.2016.02.039.[PMID] 27013060.
31 citations·PubMed·Publisher's Site
2016
Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial.
Journal of the American College of Cardiology.67(10):1145-1154[DOI] 10.1016/j.jacc.2015.12.062.[PMID] 26965534.
95 citations·PubMed·Publisher's Site
2016
Switching P2Y12-receptor inhibitors in patients with coronary artery disease.
Nature reviews. Cardiology.13(1):11-27[DOI] 10.1038/nrcardio.2015.113.[PMID] 26283269.
133 citations·PubMed·Publisher's Site
2016
The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.
Circulation journal : official journal of the Japanese Circulation Society.80(12):2429-2431[DOI] .[PMID] 27795489.
3 citations·PubMed·Publisher's Site
2016
The Paradox of Smoking and Clopidogrel Effect　- Dr Jekyll or Mr Hyde?
Circulation journal : official journal of the Japanese Circulation Society.80(7):1529-31[DOI] 10.1253/circj.CJ-16-0508.[PMID] 27302849.
2 citations·PubMed·Publisher's Site
2016
Update on oral antithrombotic therapy for secondary prevention following non-ST segment elevation myocardial infarction.
Trends in cardiovascular medicine.26(4):321-34[DOI] 10.1016/j.tcm.2015.08.002.[PMID] 26391344.
3 citations·PubMed·Publisher's Site
2015
[Non-cardiac surgery in patients with previous percutaneous coronary intervention according to the 2014 European guidelines].
Giornale italiano di cardiologia (2006).16(5):277-80[DOI] 10.1714/1870.20424.[PMID] 25994462.
PubMed·Publisher's Site
2015
Defining the link between chronic kidney disease, high platelet reactivity, and clinical outcomes in clopidogrel-treated patients undergoing percutaneous coronary intervention.
Circulation. Cardiovascular interventions.8(6):e002760-[DOI] 10.1161/CIRCINTERVENTIONS.115.002760.[PMID] 26056251.
11 citations·PubMed·Publisher's Site
2015
Impact of Escalating Loading Dose Regimens of Ticagrelor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of a Prospective Randomized Pharmacokinetic and Pharmacodynamic Investigation.
JACC. Cardiovascular interventions.8(11):1457-1467[DOI] 10.1016/j.jcin.2015.02.030.[PMID] 26404199.
66 citations·PubMed·Publisher's Site
2015
Novel antiplatelet agents in acute coronary syndrome.
Nature reviews. Cardiology.12(1):30-47[DOI] 10.1038/nrcardio.2014.156.[PMID] 25286881.
246 citations·PubMed·Publisher's Site
2015
Novel Antiplatelet Agents: The Current State and What Is Coming Down the Pike.
Progress in cardiovascular diseases.58(3):267-77[DOI] 10.1016/j.pcad.2015.08.009.[PMID] 26277706.
13 citations·PubMed·Publisher's Site
2015
Pharmacodynamic Effects of Ticagrelor Dosing Regimens in Patients on Maintenance Ticagrelor Therapy: Results From a Prospective, Randomized, Double-Blind Investigation.
JACC. Cardiovascular interventions.8(8):1075-1083[DOI] 10.1016/j.jcin.2015.02.022.[PMID] 26117466.
4 citations·PubMed·Publisher's Site
2015
Platelet thrombin receptor antagonism with vorapaxar: pharmacology and clinical trial development.
Future cardiology.11(5):547-64[DOI] 10.2217/fca.15.50.[PMID] 26406386.
13 citations·PubMed·Publisher's Site
2015
Reply: elevated serum fibrinogen: an independent link between diabetes mellitus, impaired on-clopidogrel platelet inhibition, and major adverse cardiac events after percutaneous coronary intervention.
Journal of the American College of Cardiology.65(16):1714-1715[DOI] 10.1016/j.jacc.2014.12.069.[PMID] 25908082.
PubMed·Publisher's Site
2015
Role of thromboelastography and rapid thromboelastography to assess the pharmacodynamic effects of vitamin K antagonists.
Journal of thrombosis and thrombolysis.40(1):118-25[DOI] 10.1007/s11239-014-1130-1.[PMID] 25129122.
10 citations·PubMed·Publisher's Site
2014
Cigarette smoking and antiplatelet effects of aspirin monotherapy versus clopidogrel monotherapy in patients with atherosclerotic disease: results of a prospective pharmacodynamic study.
Journal of cardiovascular translational research.7(1):53-63[DOI] 10.1007/s12265-013-9535-3.[PMID] 24395495.
21 citations·PubMed·Publisher's Site
2014
Erratum to: Pharmacodynamic effects of EV-077 in patients with diabetes mellitus and coronary artery disease on aspirin or clopidogrel monotherapy: results of an in vitro pilot investigation.
Journal of thrombosis and thrombolysis.37(3):358-[DOI] 10.1007/s11239-013-1003-z.[PMID] 24101257.
PubMed·Publisher's Site
2014
Impact of cigarette smoking on P2Y12 receptor binding activity before and after clopidogrel therapy in patients with coronary artery disease.
Journal of cardiovascular translational research.7(1):47-52[DOI] 10.1007/s12265-013-9530-8.[PMID] 24357254.
6 citations·PubMed·Publisher's Site
2014
Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery disease.
Journal of the American College of Cardiology.64(10):1005-14[DOI] 10.1016/j.jacc.2014.06.1170.[PMID] 25190236.
132 citations·PubMed·Publisher's Site
2014
Perspectives on the management of antiplatelet therapy in patients with coronary artery disease requiring cardiac and noncardiac surgery.
Current opinion in cardiology.29(6):553-63[DOI] 10.1097/HCO.0000000000000104.[PMID] 25144343.
5 citations·PubMed·Publisher's Site
2014
Pharmacodynamic effects of cangrelor on platelet P2Y12 receptor-mediated signaling in prasugrel-treated patients.
JACC. Cardiovascular interventions.7(4):426-34[DOI] 10.1016/j.jcin.2013.11.019.[PMID] 24630878.
27 citations·PubMed·Publisher's Site
2014
Pharmacodynamic effects of EV-077 in patients with diabetes mellitus and coronary artery disease on aspirin or clopidogrel monotherapy: results of an in vitro pilot investigation.
Journal of thrombosis and thrombolysis.37(2):131-8[DOI] 10.1007/s11239-013-0979-8.[PMID] 23943337.
12 citations·PubMed·Publisher's Site
2014
Platelet function testing in contemporary clinical and interventional practice.
Current treatment options in cardiovascular medicine.16(5):300-[DOI] 10.1007/s11936-014-0300-y.[PMID] 24652579.
32 citations·PubMed·Publisher's Site
2014
Unmet needs in the management of acute myocardial infarction: role of novel protease-activated receptor-1 antagonist vorapaxar.
Vascular health and risk management.10():177-88[DOI] 10.2147/VHRM.S36045.[PMID] 24729713.
14 citations·PubMed·Publisher's Site
2013
Cangrelor: a review on pharmacology and clinical trial development.
Expert review of cardiovascular therapy.11(10):1279-91[DOI] 10.1586/14779072.2013.837701.[PMID] 24138516.
47 citations·PubMed·Publisher's Site
2013
Effect of cardiac resynchronization therapy on left atrial reverse remodeling: role of echocardiographic AV delay optimization.
International journal of cardiology.167(4):1456-60[DOI] 10.1016/j.ijcard.2012.04.046.[PMID] 22560916.
9 citations·PubMed·Publisher's Site
2013
Effects of Cangrelor in Prasugrel Treated Patients: a Pharmacodynamic in Vitro Investigation
Circulation.128(22, S):-[DOI] .[PMID] .
PubMed·Publisher's Site
2013
Impact of aspirin dose on adenosine diphosphate-mediated platelet activities. Results of an in vitro pilot investigation.
Thrombosis and haemostasis.110(4):777-84[DOI] 10.1160/TH13-05-0400.[PMID] 23884248.
6 citations·PubMed·Publisher's Site
2013
Indexed maximal left atrial volume predicts response to cardiac resynchronization therapy.
International journal of cardiology.168(4):3629-33[DOI] 10.1016/j.ijcard.2013.05.028.[PMID] 23725913.
13 citations·PubMed·Publisher's Site
2013
Pharmacodynamic Effects of Ev-077 in Patients With Diabetes Mellitus On Clopidogrel Monotherapy: Results of An in Vitro Pilot Investigation
Journal of the American College of Cardiology.61():E1830-[DOI] .[PMID] .
PubMed·Publisher's Site
2013
Platelet function profiles in patients with diabetes mellitus.
Journal of cardiovascular translational research.6(3):329-45[DOI] 10.1007/s12265-013-9449-0.[PMID] 23404189.
40 citations·PubMed·Publisher's Site
2013
Update on platelet glycoprotein IIb/IIIa inhibitors: recommendations for clinical practice.
Therapeutic advances in cardiovascular disease.7(4):197-213[DOI] 10.1177/1753944713487781.[PMID] 23818658.
42 citations·PubMed·Publisher's Site

Office Information

Academic Office
5th Floor, Ambulatory Care Center
655 West 8th Street, C35
Jacksonville, FL 32209
(904) 244-2655
 francesco.franchi@jax.ufl.edu
Medical Secretary
 Monica George
(904) 244-2060
monica.george@jax.ufl.edu

Clinical Research

OPEN ENROLLMENT
AMG 423 20110203: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects with Chronic Heart Failure with Reduced Ejection Fraction
OPEN ENROLLMENT
Impact of the PCSK9 Inhibitor Evolocumab on the Pharmacodynamic Effects of Clopidogrel in Patients with Atherosclerotic Cardiovascular Disease and High On-Treatment Platelet Reactivity

Education

Medical Degree
2006 · University of Modena and Reggio Emilia, Modena, Italy
Cardiovascular Disease Fellowship
2011 · University of Modena and Reggio Emilia, Modena, Italy

News

June 26, 2023
16 UF COMJ faculty members receive promotions for 2023-24
February 16, 2021
UF Health Jacksonville is the world’s first site to test drug to prevent excessive bleeding