Sophia S. Sheikh, M.D.

Sophia S. Sheikh M.D.

Associate Professor

Department: Department of Emergency Medicine
Business Phone: (904) 244-4986
Business Email:

About Sophia S. Sheikh

Sophia Sheikh, M.D., received her degree from the University of Alabama School of Medicine at Birmingham and completed her residency training at the University of Florida School of Medicine – Jacksonville. She then pursued further training in the field of medical toxicology at the joint program offered by Emory University and the Centers for Disease Control and Prevention in Atlanta, Georgia. While learning the clinical aspects of medical toxicology, she also learned principles related to public health surveillance, epidemiology, public health and disease prevention. In addition to toxicology, she also has an interest in emergency department pain management. She is a sub-investigator on a patient safety grant working on improving pain management and education in acute care settings. She authored several publications and presented lectures nationally on these topics. Currently, she is a clinical assistant professor at the University of Florida School of Medicine – Jacksonville.

Clinical Profile

  • Emergency Medicine
  • Medical Toxicology
  • Clinical Special Interests: Medical toxicology
  • Research Special Interests: Medical toxicology


Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals.
Psychological medicine.54(2):338-349[DOI] 10.1017/S0033291723001642.[PMID] 37309917.
Emergency department management of North American snake envenomations.
Emergency medicine practice.26(Suppl 2):1-44[DOI] .[PMID] 38350100.
Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk.
Frontiers in psychiatry.15():1249382-[DOI] 10.3389/fpsyt.2024.1249382.[PMID] 38525258.
Sex differences in response inhibition-related neural predictors of PTSD in recent trauma-exposed civilians.
Biological psychiatry. Cognitive neuroscience and neuroimaging.():-[DOI] 10.1016/j.bpsc.2024.03.002.[PMID] 38522649.
A pilot study to identify pharmacogenomic and clinical risk factors associated with opioid related falls and adverse effects in older adults
Clinical and Translational Science.16(11):2331-2344[DOI] 10.1111/cts.13634.[PMID] 37705211.
Association between microbiome and the development of adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure
Translational Psychiatry.13(1):-[DOI] 10.1038/s41398-023-02643-8.[PMID] 37980332.
Derivation and Validation of a Brief Emergency Department-Based Prediction Tool for Posttraumatic Stress After Motor Vehicle Collision.
Annals of emergency medicine.81(3):249-261[DOI] 10.1016/j.annemergmed.2022.08.011.[PMID] 36328855.
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure
Molecular Psychiatry.():-[DOI] 10.1038/s41380-023-02012-3.[PMID] 36932158.
Neighborhood Disadvantage and Neural Correlates of Threat and Reward Processing in Survivors of Recent Trauma.
JAMA network open.6(9):e2334483-[DOI] 10.1001/jamanetworkopen.2023.34483.[PMID] 37721751.
Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.
Biological psychiatry global open science.3(4):705-715[DOI] 10.1016/j.bpsgos.2023.02.004.[PMID] 37881578.
Structural inequities contribute to racial/ethnic differences in neurophysiological tone, but not threat reactivity, after trauma exposure
Molecular Psychiatry.28(7):2975-2984[DOI] 10.1038/s41380-023-01971-x.[PMID] 36725899.
Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort
Translational Psychiatry.13(1):-[DOI] 10.1038/s41398-022-02289-y.[PMID] 36609484.
Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure.
JAMA psychiatry.80(3):220-229[DOI] 10.1001/jamapsychiatry.2022.4533.[PMID] 36630119.
Anxiety sensitivity as a transdiagnostic risk factor for trajectories of adverse posttraumatic neuropsychiatric sequelae in the AURORA study
Journal of Psychiatric Research.156():45-54[DOI] 10.1016/j.jpsychires.2022.09.027.[PMID] 36242943.
Characterizing OPRM1 DNA methylation in prescription opioid users with chronic musculoskeletal pain.
Pain reports.7(6):e1046-[DOI] 10.1097/PR9.0000000000001046.[PMID] .
Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms.
The Journal of neuroscience : the official journal of the Society for Neuroscience.42(34):6593-6604[DOI] 10.1523/JNEUROSCI.0911-21.2022.[PMID] 35879096.
Neurocognition after motor vehicle collision and adverse post-traumatic neuropsychiatric sequelae within 8 weeks: Initial findings from the AURORA study.
Journal of affective disorders.298(Pt B):57-67[DOI] 10.1016/j.jad.2021.10.104.[PMID] 34800569.
Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study
PLOS ONE.17(9):e0273378-[DOI] 10.1371/journal.pone.0273378.[PMID] 36149896.
Prior histories of posttraumatic stress disorder and major depression and their onset and course in the three months after a motor vehicle collision in the AURORA study.
Depression and anxiety.39(1):56-70[DOI] 10.1002/da.23223.[PMID] 34783142.
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Translational Psychiatry.12(1):-[DOI] 10.1038/s41398-022-02085-8.[PMID] 35941117.
Validating the HELP Survey to Understand Health Disparity Influence on Chronic Pain.
Journal of pain research.15():545-560[DOI] 10.2147/JPR.S338669.[PMID] 35228818.
A prospective examination of sex differences in posttraumatic autonomic functioning
Neurobiology of Stress.15():100384-[DOI] 10.1016/j.ynstr.2021.100384.[PMID] 34485632.
Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.
The American journal of psychiatry.178(11):1037-1049[DOI] 10.1176/appi.ajp.2021.20101526.[PMID] 34645277.
Classification and Prediction of Post-Trauma Outcomes Related to PTSD Using Circadian Rhythm Changes Measured via Wrist-Worn Research Watch in a Large Longitudinal Cohort
IEEE Journal of Biomedical and Health Informatics.25(8):2866-2876[DOI] 10.1109/jbhi.2021.3053909.[PMID] .
Comparing Pain Intensity Using the Numeric Rating Scale and Defense and Veterans Pain Rating Scale in Patients Revisiting the Emergency Department.
Cureus.13(8):e17501-[DOI] 10.7759/cureus.17501.[PMID] 34603880.
Development and Validation of a Model to Predict Posttraumatic Stress Disorder and Major Depression After a Motor Vehicle Collision.
JAMA psychiatry.78(11):1228-1237[DOI] 10.1001/jamapsychiatry.2021.2427.[PMID] 34468741.
Opioid Overdose Risk in Patients Returning to the Emergency Department for Pain
Pain Medicine.22(9):2100-2105[DOI] 10.1093/pm/pnab047.[PMID] 33560418.
Pain after a motor vehicle crash: The role of socio‐demographics, crash characteristics and peri‐traumatic stress symptoms
European Journal of Pain.25(5):1119-1136[DOI] 10.1002/ejp.1733.[PMID] .
Prior sleep problems and adverse post-traumatic neuropsychiatric sequelae of motor vehicle collision in the AURORA study
Sleep.44(3):-[DOI] 10.1093/sleep/zsaa200.[PMID] 32975289.
Prognostic neuroimaging biomarkers of trauma-related psychopathology: resting-state fMRI shortly after trauma predicts future PTSD and depression symptoms in the AURORA study
Neuropsychopharmacology.46(7):1263-1271[DOI] 10.1038/s41386-020-00946-8.[PMID] 33479509.
Socio-demographic and trauma-related predictors of PTSD within 8 weeks of a motor vehicle collision in the AURORA study
Molecular Psychiatry.26(7):3108-3121[DOI] 10.1038/s41380-020-00911-3.[PMID] 33077855.
Thalamic volume and fear extinction interact to predict acute posttraumatic stress severity
Journal of Psychiatric Research.141():325-332[DOI] 10.1016/j.jpsychires.2021.07.023.[PMID] 34304036.
The Toxicology Investigators Consortium 2020 Annual Report
Journal of Medical Toxicology.17(4):333-362[DOI] 10.1007/s13181-021-00854-3.[PMID] 34535889.
Predicting Pain-Related 30-Day Emergency Department Return Visits in Middle-Aged and Older Adults
Pain Medicine.21(11):2748-2756[DOI] 10.1093/pm/pnaa213.[PMID] 32875332.
Socio-demographic and trauma-related predictors of depression within eight weeks of motor vehicle collision in the AURORA study.
Psychological medicine.():1-14[DOI] 10.1017/S0033291720003773.[PMID] 33118917.
Risk Factors Associated with Emergency Department Recidivism in the Older Adult.
The western journal of emergency medicine.20(6):931-938[DOI] 10.5811/westjem.2019.7.43073.[PMID] 31738721.
Emergency department management of North American snake envenomations.
Emergency medicine practice.20(9):1-26[DOI] .[PMID] 30130010.
Points & Pearls: Emergency department management of North American snake envenomations.
Emergency medicine practice.20(19 Suppl):1-2[DOI] .[PMID] 30179413.
The Expanding Role of Ketamine in the Emergency Department
Drugs.78(7):727-735[DOI] 10.1007/s40265-018-0904-8.[PMID] .
Female With Vaginal Spotting.
Annals of emergency medicine.70(1):e1-e2[DOI] 10.1016/j.annemergmed.2017.01.012.[PMID] 28645417.
Assessing patient activation and health literacy in the ED.
The American journal of emergency medicine.34(1):93-6[DOI] 10.1016/j.ajem.2015.09.045.[PMID] 26508580.
Response to Comments on "Poisonings with Suicidal Intent Aged 0-21 Years Reported to Poison Centers 2003-12".
The western journal of emergency medicine.17(1):94-6[DOI] 10.5811/westjem.2015.12.29429.[PMID] 26823943.
Poisonings with Suicidal Intent Aged 0-21 Years Reported to Poison Centers 2003-12.
The western journal of emergency medicine.16(4):497-502[DOI] 10.5811/westjem.2015.5.25459.[PMID] 26265960.
Comparison of Iatrogenic Adverse Drug Events Occurring in Hospital and Community Settings Reported To Three Poison Centers
Clinical Toxicology.52(7):691-692[DOI] .[PMID] .
Incidents of potential public health significance identified using national surveillance of US poison center data (2008–2012)
Clinical Toxicology.52(9):958-963[DOI] 10.3109/15563650.2014.953171.[PMID] 25175899.
Characterizing risk factors for pediatric lamp oil product exposures
Clinical Toxicology.51(9):871-878[DOI] 10.3109/15563650.2013.839028.[PMID] 24066734.
Passive Multistate Surveillance for Neutropenia After Use of Cocaine or Heroin Possibly Contaminated With Levamisole
Annals of Emergency Medicine.61(4):468-474[DOI] 10.1016/j.annemergmed.2012.10.036.[PMID] .
Do-Not-Resuscitate Orders in Fatal Toxic Exposures: A Poison Center's Review.
The western journal of emergency medicine.13(3):294-7[DOI] 10.5811/westjem.2012.3.11725.[PMID] 22928059.
Exotic venomous snakebite drill
Clinical Toxicology.50(6):490-496[DOI] 10.3109/15563650.2012.690882.[PMID] .
Radiological preparedness-awareness and attitudes: A cross–sectional survey of emergency medicine residents and physicians at three academic institutions in the United States
Clinical Toxicology.50(1):34-38[DOI] 10.3109/15563650.2011.637047.[PMID] .

Office Information

Academic Office
1st Floor, Clinical Center
655 West 8th Street
Jacksonville, FL 32209
(904) 244-4986
Executive Assistant
Amy Kennedy
(904) 244-4986


Medical Degree
2007 · University of Alabama School of Medicine, Birmingham, AL, USA
Emergency Medicine Residency
2010 · University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA
Medical Toxicology Fellowship
2012 · Emory University School of Medicine, Atlanta, GA, USA