Charles W. Heilig, M.D.

Charles W. Heilig M.D.

Professor & Chief, Division of Nephrology and Hypertension; Program Director, Nephrology Fellowship

Department: Department of Medicine
Business Phone: (904) 244-5964
Business Email: charles.heilig@jax.ufl.edu

Board Certifications

  • Internal Medicine
  • Nephrology

Clinical Profile

Specialties
  • Nephrology
Interests
  • Clinical Special Interests: Diabetic kidney disease and the progression of chronic renal failure
  • Research Special Interests: Roles for glucose transporters in diabetic kidney disease and in the progression of chronic glomerular disease

Publications

2021
Predictors of disease severity and outcome of hospitalized renal transplant recipients with COVID-19 infection: a systematic review of a globally representative sample.
Romanian journal of internal medicine = Revue roumaine de medecine interne.59(1):10-42[DOI] 10.2478/rjim-2020-0034.[PMID] 33155999.
2020
Liberation from Dialysis Dependence in a Patient with HIV-Associated Nephropathy (HIVAN) after Combined Antiretroviral Therapy (cART).
Case reports in nephrology.2020():7294765-[DOI] 10.1155/2020/7294765.[PMID] 32257472.
2019
Effect of race and ethnicity on renal transplant referral
.
Clinical nephrology.92(5):221-225[DOI] 10.5414/CN109858.[PMID] 31496515.
2016
A Unique Cause of Proteinuria in Pregnancy: Class II Lupus Nephritis with Concomitant Minimal Change Disease.
Case reports in nephrology and dialysis.6(3):101-105[DOI] .[PMID] 27781205.
2015
Minimal Change Disease On Top of Lupus Nephritis Class II
.65(4):A15-[DOI] .[PMID] .
2013
GLUT1 regulation of the pro-sclerotic mediators of diabetic nephropathy.
American journal of nephrology.38(1):39-49[DOI] 10.1159/000351989.[PMID] 23817135.
2012
Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.
Neurobiology of disease.48(1):92-101[DOI] 10.1016/j.nbd.2012.04.011.[PMID] 22683290.
2011
Comparative Analysis of the Effect of Darbepoetin To Erythopoetin On Goal Hematocrit Level in a Hemodialysis Population
Journal of Investigative Medicine.59():329-[DOI] .[PMID] .
2011
Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study.
BMC medical genetics.12():16-[DOI] 10.1186/1471-2350-12-16.[PMID] 21247498.
2011
GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
American journal of physiology. Renal physiology.301(3):F588-96[DOI] 10.1152/ajprenal.00472.2010.[PMID] 21613414.
2011
Kidney Expression of the Type 1 Glucose Transporter in Chronic Allograft Nephropathy
Journal of Investigative Medicine.59():570-[DOI] .[PMID] .
2010
Comparison of Time To Bacteremia in Hiv Infected Hemodialysis Patients From the 1996 and 2004 Usrds Datasets
Journal of Investigative Medicine.58():270-[DOI] .[PMID] .
2010
Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.
Laboratory investigation; a journal of technical methods and pathology.90(1):83-97[DOI] 10.1038/labinvest.2009.95.[PMID] 19918242.
2010
Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice.
American journal of physiology. Renal physiology.299(1):F91-8[DOI] 10.1152/ajprenal.00021.2010.[PMID] 20375116.
2010
Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis.
American journal of physiology. Renal physiology.299(1):F99-F111[DOI] 10.1152/ajprenal.00466.2009.[PMID] 20375117.
2009
Bacteremia Rates in Hiv Infected Hemodialysis Patients: a Comparative Analysis of 1996 and 2004 Usrds Datasets
Journal of Investigative Medicine.57():415-[DOI] .[PMID] .
2009
Glut-1, Ace2 and Angiotensin II Degradation in Mesangial Cells
Hypertension.54():E113-[DOI] .[PMID] .
2009
GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells.
American journal of physiology. Cell physiology.297(3):C759-65[DOI] 10.1152/ajpcell.00213.2009.[PMID] 19587217.
2006
Accuracy of Papanicolaou test among HIV-infected women.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.42(4):562-8[DOI] .[PMID] 16421802.
2006
Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy.
Kidney international.70(5):882-91[DOI] .[PMID] 16820793.
2006
Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.18(4-5):199-210[DOI] .[PMID] 17167225.
2006
Role for GLUT1 in diabetic glomerulosclerosis.
Expert reviews in molecular medicine.8(4):1-18[DOI] .[PMID] 16515729.
2005
Diabetic nephropathy: of mice and men.
Advances in chronic kidney disease.12(2):128-45[DOI] .[PMID] 15822049.
2005
Glucose transporters in diabetic nephropathy.
Pediatric nephrology (Berlin, Germany).20(4):447-51[DOI] .[PMID] 15717166.
2005
Mouse models of diabetic nephropathy.
Journal of the American Society of Nephrology : JASN.16(1):27-45[DOI] .[PMID] 15563560.
2004
GLUT1-deficient mice exhibit impaired endothelium-dependent vascular relaxation.
European journal of pharmacology.496(1-3):213-4[DOI] .[PMID] 15288593.
2003
Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters.
Diabetes.52(2):527-35[DOI] .[PMID] 12540631.
2003
Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy.
Proceedings of the National Academy of Sciences of the United States of America.100(26):15613-8[DOI] .[PMID] 14673082.
2003
Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress.
The American journal of pathology.163(5):1873-85[DOI] .[PMID] 14578187.
2003
Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1.
Kidney international.64(4):1338-47[DOI] .[PMID] 12969152.
2001
Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression.
American journal of physiology. Renal physiology.280(4):F657-66[DOI] .[PMID] 11249857.
2001
Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine.
American journal of kidney diseases : the official journal of the National Kidney Foundation.37(5):1039-43[DOI] .[PMID] 11325687.
1999
Glucose transporters control gene expression of aldose reductase, PKCalpha, and GLUT1 in mesangial cells in vitro.
The American journal of physiology.277(1):F97-104[DOI] 10.1152/ajprenal.1999.277.1.F97.[PMID] 10409302.
1997
D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells: implications for diabetic nephropathy.
Diabetes.46(6):1030-9[DOI] .[PMID] 9166676.
1997
Glucose transporters of the glomerulus and the implications for diabetic nephropathy.
Kidney international. Supplement.60():S91-9[DOI] .[PMID] 9285909.
1996
Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells.
The American journal of pathology.148(6):1915-23[DOI] .[PMID] 8669477.
1995
Immunogold localization of high-affinity glucose transporter isoforms in normal rat kidney.
Laboratory investigation; a journal of technical methods and pathology.73(5):674-84[DOI] .[PMID] 7474941.
1995
Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype.
The Journal of clinical investigation.96(4):1802-14[DOI] .[PMID] 7560072.

Office Information

Academic Office
4th Floor, Ambulatory Care Center
655 West 8th Street, C290
Jacksonville, FL 32209
(904) 244-5964
charles.heilig@jax.ufl.edu
Administrative Manager
Sandy Caroccio
(904) 244-5964
casandra.caroccio@jax.ufl.edu
GME Office
5th Floor, Tower 1, Suite 513
580 West 8th Street
Jacksonville, FL 32209
Phone: (904) 244-3092
Fax: (904) 244-2165
charles.heilig@jax.ufl.edu
Senior GME Program Administrator
Jessica McDonald-Jazrawi, MBA, C-TAGME
(904) 244-3092
jessica.mcdonald-jazrawi2@jax.ufl.edu

Education

Medical Degree
1984 · University of Minnesota Medical School, Minneapolis, MN, USA
Internal Medicine Residency
1987 · Mayo Graduate School of Medicine, Rochester, MN, USA
Nephrology Fellowship
1990 · Harvard Medical School, Boston, MA, USA