Charles W. Heilig, M.D.

Charles W. Heilig M.D.

Professor & Chief, Division of Nephrology and Hypertension; Program Director, Nephrology Fellowship

Department: Department of Medicine
Business Phone: (904) 244-5964
Business Email:

Board Certifications

  • Internal Medicine
  • Nephrology

Clinical Profile

  • Nephrology
  • Clinical Special Interests: Diabetic kidney disease and the progression of chronic renal failure
  • Research Special Interests: Roles for glucose transporters in diabetic kidney disease and in the progression of chronic glomerular disease


SGLT2 inhibitors: Beyond glycemic control.
Journal of clinical & translational endocrinology.35():100335-[DOI] 10.1016/j.jcte.2024.100335.[PMID] 38525377.
Predictors of disease severity and outcome of hospitalized renal transplant recipients with COVID-19 infection: a systematic review of a globally representative sample.
Romanian journal of internal medicine = Revue roumaine de medecine interne.59(1):10-42[DOI] 10.2478/rjim-2020-0034.[PMID] 33155999.
Liberation from Dialysis Dependence in a Patient with HIV-Associated Nephropathy (HIVAN) after Combined Antiretroviral Therapy (cART).
Case reports in nephrology.2020():7294765-[DOI] 10.1155/2020/7294765.[PMID] 32257472.
Effect of race and ethnicity on renal transplant referral
Clinical nephrology.92(5):221-225[DOI] 10.5414/CN109858.[PMID] 31496515.
A Unique Cause of Proteinuria in Pregnancy: Class II Lupus Nephritis with Concomitant Minimal Change Disease.
Case reports in nephrology and dialysis.6(3):101-105[DOI] .[PMID] 27781205.
Minimal Change Disease On Top of Lupus Nephritis Class II
.65(4):A15-[DOI] .[PMID] .
GLUT1 regulation of the pro-sclerotic mediators of diabetic nephropathy.
American journal of nephrology.38(1):39-49[DOI] 10.1159/000351989.[PMID] 23817135.
Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.
Neurobiology of disease.48(1):92-101[DOI] 10.1016/j.nbd.2012.04.011.[PMID] 22683290.
Comparative Analysis of the Effect of Darbepoetin To Erythopoetin On Goal Hematocrit Level in a Hemodialysis Population
Journal of Investigative Medicine.59():329-[DOI] .[PMID] .
Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) study.
BMC medical genetics.12():16-[DOI] 10.1186/1471-2350-12-16.[PMID] 21247498.
GLUT1 enhances mTOR activity independently of TSC2 and AMPK.
American journal of physiology. Renal physiology.301(3):F588-96[DOI] 10.1152/ajprenal.00472.2010.[PMID] 21613414.
Kidney Expression of the Type 1 Glucose Transporter in Chronic Allograft Nephropathy
Journal of Investigative Medicine.59():570-[DOI] .[PMID] .
Comparison of Time To Bacteremia in Hiv Infected Hemodialysis Patients From the 1996 and 2004 Usrds Datasets
Journal of Investigative Medicine.58():270-[DOI] .[PMID] .
Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.
Laboratory investigation; a journal of technical methods and pathology.90(1):83-97[DOI] 10.1038/labinvest.2009.95.[PMID] 19918242.
Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice.
American journal of physiology. Renal physiology.299(1):F91-8[DOI] 10.1152/ajprenal.00021.2010.[PMID] 20375116.
Transgenic overexpression of GLUT1 in mouse glomeruli produces renal disease resembling diabetic glomerulosclerosis.
American journal of physiology. Renal physiology.299(1):F99-F111[DOI] 10.1152/ajprenal.00466.2009.[PMID] 20375117.
Bacteremia Rates in Hiv Infected Hemodialysis Patients: a Comparative Analysis of 1996 and 2004 Usrds Datasets
Journal of Investigative Medicine.57():415-[DOI] .[PMID] .
Glut-1, Ace2 and Angiotensin II Degradation in Mesangial Cells
Hypertension.54():E113-[DOI] .[PMID] .
GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells.
American journal of physiology. Cell physiology.297(3):C759-65[DOI] 10.1152/ajpcell.00213.2009.[PMID] 19587217.
Accuracy of Papanicolaou test among HIV-infected women.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.42(4):562-8[DOI] .[PMID] 16421802.
Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy.
Kidney international.70(5):882-91[DOI] .[PMID] 16820793.
Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.18(4-5):199-210[DOI] .[PMID] 17167225.
Role for GLUT1 in diabetic glomerulosclerosis.
Expert reviews in molecular medicine.8(4):1-18[DOI] .[PMID] 16515729.
Diabetic nephropathy: of mice and men.
Advances in chronic kidney disease.12(2):128-45[DOI] .[PMID] 15822049.
Glucose transporters in diabetic nephropathy.
Pediatric nephrology (Berlin, Germany).20(4):447-51[DOI] .[PMID] 15717166.
Mouse models of diabetic nephropathy.
Journal of the American Society of Nephrology : JASN.16(1):27-45[DOI] .[PMID] 15563560.
GLUT1-deficient mice exhibit impaired endothelium-dependent vascular relaxation.
European journal of pharmacology.496(1-3):213-4[DOI] .[PMID] 15288593.
Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters.
Diabetes.52(2):527-35[DOI] .[PMID] 12540631.
Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy.
Proceedings of the National Academy of Sciences of the United States of America.100(26):15613-8[DOI] .[PMID] 14673082.
Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress.
The American journal of pathology.163(5):1873-85[DOI] .[PMID] 14578187.
Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1.
Kidney international.64(4):1338-47[DOI] .[PMID] 12969152.
Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression.
American journal of physiology. Renal physiology.280(4):F657-66[DOI] .[PMID] 11249857.
Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine.
American journal of kidney diseases : the official journal of the National Kidney Foundation.37(5):1039-43[DOI] .[PMID] 11325687.
Glucose transporters control gene expression of aldose reductase, PKCalpha, and GLUT1 in mesangial cells in vitro.
The American journal of physiology.277(1):F97-104[DOI] 10.1152/ajprenal.1999.277.1.F97.[PMID] 10409302.
D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells: implications for diabetic nephropathy.
Diabetes.46(6):1030-9[DOI] .[PMID] 9166676.
Glucose transporters of the glomerulus and the implications for diabetic nephropathy.
Kidney international. Supplement.60():S91-9[DOI] .[PMID] 9285909.
Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells.
The American journal of pathology.148(6):1915-23[DOI] .[PMID] 8669477.
Immunogold localization of high-affinity glucose transporter isoforms in normal rat kidney.
Laboratory investigation; a journal of technical methods and pathology.73(5):674-84[DOI] .[PMID] 7474941.
Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype.
The Journal of clinical investigation.96(4):1802-14[DOI] .[PMID] 7560072.

Office Information

Academic Office
4th Floor, Ambulatory Care Center
655 West 8th Street, C290
Jacksonville, FL 32209
(904) 244-5964
Administrative Manager
Sandy Caroccio
(904) 244-5964
GME Office
5th Floor, Tower 1, Suite 513
580 West 8th Street
Jacksonville, FL 32209
Phone: (904) 244-3092
Fax: (904) 244-2165
Senior GME Program Administrator
Jessica McDonald-Jazrawi, MBA, C-TAGME
(904) 244-3092


Medical Degree
1984 · University of Minnesota Medical School, Minneapolis, MN, USA
Internal Medicine Residency
1987 · Mayo Graduate School of Medicine, Rochester, MN, USA
Nephrology Fellowship
1990 · Harvard Medical School, Boston, MA, USA