K.C. Balaji, M.B.B.S. (M.D.), FRCS, MRCS, LRCP

K.C. Balaji M.B.B.S. (M.D.), FRCS, MRCS, LRCP

Professor & Chair, Department of Urology; Program Director, Advanced Urology Fellowship

Department: Department of Urology
Business Phone: (904) 244-7340

About K.C. Balaji

Dr. Balaji is widely known as a pioneer in the field of robotic surgery. He is highly regarded as an expert in managing advanced urological cancers of the prostate, bladder, kidney, testes and penis.

Board Certifications

  • Urology

Clinical Profile

Specialties
  • Urologic Oncology
  • Urology

Publications

2023
Does care fragmentation in patients with bladder cancer lead to worse outcomes?
Urologic Oncology: Seminars and Original Investigations.41(3):147.e7-147.e14[DOI] 10.1016/j.urolonc.2022.10.028.[PMID] .
2023
Extramural venous invasion: a novel magnetic resonance imaging biomarker for adverse pathology in bladder cancer.
American journal of clinical and experimental urology.11(2):185-193[DOI] .[PMID] 37168940.
2023
Genetic mutations in smoking-associated prostate cancer.
The Prostate.83(13):1229-1237[DOI] 10.1002/pros.24554.[PMID] 37455402.
2023
Glomerular hyperfiltration is a predictor of adverse outcomes following major urologic oncology surgery.
International urology and nephrology.55(2):229-239[DOI] 10.1007/s11255-022-03400-4.[PMID] 36318406.
2023
Magnetic resonance imaging radiomic features for recurrent prostate cancer following proton radiation therapy-A pilot study.
Urologic oncology.41(3):145.e1-145.e5[DOI] 10.1016/j.urolonc.2022.10.007.[PMID] 36496342.
2023
MRI-based nomograms and radiomics in presurgical prediction of extraprostatic extension in prostate cancer: a systematic review.
Abdominal radiology (New York).48(7):2379-2400[DOI] 10.1007/s00261-023-03924-y.[PMID] 37142824.
2023
Natural history, and impact of surgery and radiation on survival outcomes of men diagnosed with low-grade prostate cancer at ≤ 55 years of age: a 25-year follow-up of > 60,000 men.
International urology and nephrology.55(2):295-300[DOI] 10.1007/s11255-022-03363-6.[PMID] 36171482.
2023
Potential role for protein kinase D inhibitors in prostate cancer.
Journal of molecular medicine (Berlin, Germany).101(4):341-349[DOI] 10.1007/s00109-023-02298-4.[PMID] 36843036.
2023
The geriatric nutritional risk index predicts complications after nephrectomy for renal cancer.
International braz j urol : official journal of the Brazilian Society of Urology.49(1):97-109[DOI] 10.1590/S1677-5538.IBJU.2022.0380.[PMID] 36512458.
2023
The impact of socioeconomic status on the survival of men with early-onset prostate cancer.
American journal of clinical and experimental urology.11(2):146-154[DOI] .[PMID] 37168939.
2023
Urinary stone disease burden is increased in patients with cognitive impairment.
American journal of clinical and experimental urology.11(3):249-257[DOI] .[PMID] 37441445.
2022
3JC48-3 (methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth
Cancer Gene Therapy.29(11):1550-1557[DOI] 10.1038/s41417-022-00455-4.[PMID] .
2022
Complications after neoadjuvant chemotherapy and radical cystectomy for patients with bladder cancer: A propensity score matched analysis.
Canadian Urological Association journal = Journal de l'Association des urologues du Canada.():-[DOI] 10.5489/cuaj.7952.[PMID] 36473472.
2022
Diagnostic accuracy of vesical imaging-reporting and data system (VI-RADS) in suspected muscle invasive bladder cancer: A systematic review and diagnostic meta-analysis.
Urologic oncology.40(2):45-55[DOI] 10.1016/j.urolonc.2021.11.008.[PMID] 34895996.
2022
Inter-reader reliability of the vesical imaging-reporting and data system (VI-RADS) for muscle-invasive bladder cancer: a systematic review and meta-analysis.
Abdominal radiology (New York).47(12):4173-4185[DOI] 10.1007/s00261-022-03669-0.[PMID] 36112202.
2022
The Geriatric Nutritional Risk Index Predicts Postoperative Outcomes in Bladder Cancer: A Propensity Score-Matched Analysis.
The Journal of urology.207(4):797-804[DOI] 10.1097/JU.0000000000002342.[PMID] 34854753.
2021
An Indirect Comparison of Newer Minimally Invasive Treatments for Benign Prostatic Hyperplasia: A Network Meta-Analysis Model.
Journal of endourology.35(4):409-416[DOI] 10.1089/end.2020.0739.[PMID] 32962442.
2021
Intracorporeal versus extracorporeal urinary diversion following robot-assisted radical cystectomy: a meta-analysis, cumulative analysis, and systematic review.
Journal of robotic surgery.15(3):321-333[DOI] 10.1007/s11701-020-01174-4.[PMID] 33222043.
2021
MRI and CT bladder segmentation from classical to deep learning based approaches: Current limitations and lessons.
Computers in biology and medicine.134():104472-[DOI] 10.1016/j.compbiomed.2021.104472.[PMID] 34023696.
2021
Pathology grade influences competing mortality risks in elderly men with prostate cancer.
Urologic oncology.39(8):493.e1-493.e7[DOI] 10.1016/j.urolonc.2020.12.004.[PMID] 33353870.
2021
Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: What about the Negatives?
Radiology.298(1):E57-[DOI] 10.1148/radiol.2020202870.[PMID] 33141006.
2020
A Systematic Review and Meta-Analysis of Methods Used to Reduce Infectious Complications Following Transrectal Prostate Biopsy.
Urology.144():21-27[DOI] 10.1016/j.urology.2020.06.005.[PMID] 32569659.
2020
Comparative efficacy of apalutamide darolutamide and enzalutamide for treatment of non-metastatic castrate-resistant prostate cancer: A systematic review and network meta-analysis.
Urologic oncology.38(11):826-834[DOI] 10.1016/j.urolonc.2020.03.022.[PMID] 32605736.
2020
Meta-analysis and systematic review of intermediate-term follow-up of prostatic urethral lift for benign prostatic hyperplasia.
International urology and nephrology.52(6):999-1008[DOI] 10.1007/s11255-020-02408-y.[PMID] 32065331.
2020
Re: Antibiotic Prophylaxis for the Prevention of Infectious Complications following Prostate Biopsy: A Systematic Review and Meta-AnalysisA. Pilatz, K. Dimitropoulos, R. Veeratterapillay, Y. Yuan, M. I. Omar, S. MacLennan, T. Cai, F. Bruyère, R. Bartoletti, B. Köves, F. Wagenlehner, G. Bonkat and B. Pradere J Urol 2020; 204: 224-230.
The Journal of urology.204(6):1349-1350[DOI] 10.1097/JU.0000000000001332.[PMID] 32830995.
2020
Symptomatic Pituitary Metastasis as Initial Manifestation of Renal Cell Carcinoma: Case Report and Review of Literature.
Case reports in endocrinology.2020():8883864-[DOI] 10.1155/2020/8883864.[PMID] 32908722.
2019
Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25.
The Prostate.79(9):1053-1058[DOI] 10.1002/pros.23807.[PMID] 30958903.
2017
Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.
Oncotarget.8(45):78811-78824[DOI] 10.18632/oncotarget.20229.[PMID] 29108267.
2016
Cell line modeling to study biomarker panel in prostate cancer.
The Prostate.76(3):245-58[DOI] 10.1002/pros.23116.[PMID] 26764245.
2016
E-Cadherin Facilitates Protein Kinase D1 Activation and Subcellular Localization.
Journal of cellular physiology.231(12):2741-8[DOI] 10.1002/jcp.25382.[PMID] 26991955.
2016
Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells.
Nanomedicine (London, England).11(10):1207-22[DOI] 10.2217/nnm-2015-0017.[PMID] 27077564.
2016
Rapid bench to bed in management of metastatic prostate cancer.
Indian journal of urology : IJU : journal of the Urological Society of India.32(4):255-256[DOI] .[PMID] 27843205.
2015
Editorial comment.
The Journal of urology.193(6):1916-7; discussion 1917[DOI] 10.1016/j.juro.2014.12.107.[PMID] 25770361.
2015
Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate.
The Prostate.75(9):988-1000[DOI] 10.1002/pros.22984.[PMID] 25753731.
2015
The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
The Prostate.75(4):360-9[DOI] 10.1002/pros.22922.[PMID] 25408502.
2014
Autophagy: friend or foe for progression and treatment of urothelial carcinoma.
The Journal of urology.191(6):1644-5[DOI] 10.1016/j.juro.2014.03.082.[PMID] 24647081.
2013
Preoperative neutrophil/lymphocyte ratio predicts overall survival and extravesical disease in patients undergoing radical cystectomy.
Journal of endourology.27(8):1046-50[DOI] 10.1089/end.2012.0606.[PMID] 23517015.
2010
Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.
Cancer research.70(5):2095-104[DOI] 10.1158/0008-5472.CAN-09-4155.[PMID] 20160036.
2010
Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail.
Cancer research.70(20):7810-9[DOI] 10.1158/0008-5472.CAN-09-4481.[PMID] 20940406.
2010
Robotic partial cystectomy for bladder cancer: a single-institutional pilot study.
Journal of endourology.24(2):223-7[DOI] 10.1089/end.2009.0367.[PMID] 20039797.
2009
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.
Oncogene.28(49):4386-96[DOI] 10.1038/onc.2009.291.[PMID] 19767773.
2009
Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin.
Cancer research.69(3):1117-24[DOI] 10.1158/0008-5472.CAN-07-6270.[PMID] 19141652.
2008
Beta-catenin mediates alteration in cell proliferation, motility and invasion of prostate cancer cells by differential expression of E-cadherin and protein kinase D1.
Journal of cellular biochemistry.104(1):82-95[DOI] .[PMID] 17979146.
2008
Bryostatin 1 modulates beta-catenin subcellular localization and transcription activity through protein kinase D1 activation.
Molecular cancer therapeutics.7(9):2703-12[DOI] 10.1158/1535-7163.MCT-08-0119.[PMID] 18765827.
2008
Protein kinase D1 (PKD1) influences androgen receptor (AR) function in prostate cancer cells.
Biochemical and biophysical research communications.373(4):618-23[DOI] 10.1016/j.bbrc.2008.06.097.[PMID] 18602367.
2007
Major urological oncological surgeries can be performed using minimally invasive robotic or laparoscopic methods with similar early perioperative outcomes compared to conventional open methods.
World journal of urology.25(2):193-8[DOI] .[PMID] 17171562.
2006
Comparative analysis of early perioperative outcomes following radical cystectomy by either the robotic or open method.
JSLS : Journal of the Society of Laparoendoscopic Surgeons.10(2):145-50[DOI] .[PMID] 16882409.
2006
Metallothioneins and resistance to cisplatin and radiation in prostate cancer.
Urology.67(6):1341-7[DOI] .[PMID] 16765200.
2006
N-cadherin switching occurs in high Gleason grade prostate cancer.
The Prostate.66(2):193-9[DOI] .[PMID] 16173043.
2006
Radical nephrectomy performed by open, laparoscopy with or without hand-assistance or robotic methods by the same surgeon produces comparable perioperative results.
International braz j urol : official journal of the Brazilian Society of Urology.32(1):15-22[DOI] .[PMID] 16519823.
2005
Aberrant expression of E-cadherin and beta-catenin in human prostate cancer.
Urologic oncology.23(6):402-6[DOI] .[PMID] 16301117.
2005
E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer.
Cancer research.65(2):483-92[DOI] .[PMID] 15695390.
2005
Feasibility of robotic radical nephrectomy--initial results of single-institution pilot study.
Urology.65(6):1086-9[DOI] .[PMID] 15913733.
2005
Robotic transperitoneal detrusor myotomy: description of a novel technique.
Journal of endourology.19(4):476-9[DOI] .[PMID] 15910260.
2005
Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer.
Urologic oncology.23(6):407-12[DOI] .[PMID] 16301118.
2004
Feasibility of robot-assisted totally intracorporeal laparoscopic ileal conduit urinary diversion: initial results of a single institutional pilot study.
Urology.63(1):51-5[DOI] .[PMID] 14751347.
2004
Microarray analysis of differential gene expression in androgen independent prostate cancer using a metastatic human prostate cancer cell line model.
Urologic oncology.22(4):313-20[DOI] .[PMID] 15283889.
2003
Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer.
Biochemical and biophysical research communications.310(3):1032-8[DOI] .[PMID] 14550308.
2003
Protein kinase C mu is down-regulated in androgen-independent prostate cancer.
Biochemical and biophysical research communications.307(2):254-60[DOI] .[PMID] 12859948.
2002
Increasing incidence of all stages of kidney cancer in the last 2 decades in the United States: an analysis of surveillance, epidemiology and end results program data.
The Journal of urology.167(1):57-60[DOI] .[PMID] 11743275.
2001
Growth of heterotopic LNCaP prostate cancer tumor in nude mice is not affected by dietary calcium.
The Prostate.48(4):265-73[DOI] .[PMID] 11536306.
2000
Concordant prune belly syndrome in monozygotic twins.
Urology.55(6):949-[DOI] .[PMID] 10840120.
1999
Effect of neoadjuvant hormonal therapy on prostatic intraepithelial neoplasia and its prognostic significance.
The Journal of urology.162(3 Pt 1):753-7[DOI] .[PMID] 10458359.
1999
Upper tract recurrences following radical cystectomy: an analysis of prognostic factors, recurrence pattern and stage at presentation.
The Journal of urology.162(5):1603-6[DOI] .[PMID] 10524877.
1997
Antiproliferative effects of c-myc antisense oligonucleotide in prostate cancer cells: a novel therapy in prostate cancer.
Urology.50(6):1007-15[DOI] .[PMID] 9426742.
1997
Effect of vitamin C on prostate cancer cells in vitro: effect on cell number, viability, and DNA synthesis.
The Prostate.32(3):188-95[DOI] .[PMID] 9254898.
1995
Laparoscopic diagnosis and management of transverse testicular ectopia.
Urology.46(6):879-80[DOI] .[PMID] 7502436.

Office Information

Academic Office
2nd Floor, Faculty Clinic
653 West 8th Street, FC12
Jacksonville, FL 32209
(904) 244-7340
Kethandapatti.Balaji@jax.ufl.edu
Senior Medical Secretary
Melanie Prescott
(904) 244-7340
Melanie.Prescott@jax.ufl.edu
GME Office
2nd Floor, Faculty Clinic
653 West 8th Street, FC12
Jacksonville, FL 32209
Phone: (904) 244-7281
Fax: (904) 244-7422
Kethandapatti.Balaji@jax.ufl.edu
Program Coordinator
Shahriar Koochekpour
(904) 244-7281
Shahriar.koochekpour@jax.ufl.edu

Education

Medical Degree
1986 · Madras Medical College, Park Town, India
Urology Residency
1997 · University of Massachusetts Medical Center, Worcester, MA, USA
Urologic Oncology Fellowship
1999 · Memorial Sloan-Kettering Cancer Center, New York, NY, USA