Shahriar Koochekpour, M.D., Ph.D.

Shahriar Koochekpour M.D., Ph.D.

Professor & Associate Director for Education and Research

Department: Department of Urology
Business Phone: (904) 244-7340

Clinical Profile

Specialties
  • Biochemistry

Publications

2021
An Indirect Comparison of Newer Minimally Invasive Treatments for Benign Prostatic Hyperplasia: A Network Meta-Analysis Model.
Journal of endourology.35(4):409-416[DOI] 10.1089/end.2020.0739.[PMID] 32962442.
2021
Intracorporeal versus extracorporeal urinary diversion following robot-assisted radical cystectomy: a meta-analysis, cumulative analysis, and systematic review.
Journal of robotic surgery.15(3):321-333[DOI] 10.1007/s11701-020-01174-4.[PMID] 33222043.
2021
Pathology grade influences competing mortality risks in elderly men with prostate cancer.
Urologic oncology.39(8):493.e1-493.e7[DOI] 10.1016/j.urolonc.2020.12.004.[PMID] 33353870.
2020
A Systematic Review and Meta-Analysis of Methods Used to Reduce Infectious Complications Following Transrectal Prostate Biopsy.
Urology.144():21-27[DOI] 10.1016/j.urology.2020.06.005.[PMID] 32569659.
2020
Comparative efficacy of apalutamide darolutamide and enzalutamide for treatment of non-metastatic castrate-resistant prostate cancer: A systematic review and network meta-analysis.
Urologic oncology.38(11):826-834[DOI] 10.1016/j.urolonc.2020.03.022.[PMID] 32605736.
2019
Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression.
Translational oncology.12(8):1056-1071[DOI] 10.1016/j.tranon.2019.05.002.[PMID] 31174057.
2019
Predictive and targeting value of IGFBP-3 in therapeutically resistant prostate cancer.
American journal of clinical and experimental urology.7(3):188-202[DOI] .[PMID] 31317059.
2019
Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells.
The Prostate.79(2):140-150[DOI] 10.1002/pros.23719.[PMID] 30280407.
2018
BMI1 Drives Metastasis of Prostate Cancer in Caucasian and African-American Men and Is A Potential Therapeutic Target: Hypothesis Tested in Race-specific Models.
Clinical cancer research : an official journal of the American Association for Cancer Research.24(24):6421-6432[DOI] 10.1158/1078-0432.CCR-18-1394.[PMID] 30087142.
2017
Androgen receptor splice variants and prostate cancer: From bench to bedside.
Oncotarget.8(11):18550-18576[DOI] 10.18632/oncotarget.14537.[PMID] 28077788.
2017
Reversion of epithelial-mesenchymal transition by a novel agent DZ-50 via IGF binding protein-3 in prostate cancer cells.
Oncotarget.8(45):78507-78519[DOI] 10.18632/oncotarget.19659.[PMID] 29108245.
2016
Characterization of fibroblast-free CWR-R1ca castration-recurrent prostate cancer cell line.
The Prostate.76(12):1067-77[DOI] 10.1002/pros.23190.[PMID] 27271795.
2016
GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models.
Clinical cancer research : an official journal of the American Association for Cancer Research.():-[DOI] 10.1158/1078-0432.CCR-16-0137.[PMID] 27458247.
2016
Mitochondrial dysfunction-mediated apoptosis resistance associates with defective heat shock protein response in African-American men with prostate cancer.
British journal of cancer.114(10):1090-100[DOI] 10.1038/bjc.2016.88.[PMID] 27115471.
2016
Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer.
Oncotarget.7(39):64447-64470[DOI] 10.18632/oncotarget.10901.[PMID] 27487144.
2016
Therapeutic Rationales, Progresses, Failures, and Future Directions for Advanced Prostate Cancer.
International journal of biological sciences.12(4):409-26[DOI] 10.7150/ijbs.14090.[PMID] 27019626.
2015
Commentary on "Region 2 of 8q24 is associated with the risk of aggressive prostate cancer in Caribbean men of African descent from Guadeloupe (French West Indies)".
Asian journal of andrology.17(1):160-[DOI] 10.4103/1008-682X.143305.[PMID] 25475665.
2014
Androgen receptor mutations and polymorphisms in African American prostate cancer.
International journal of biological sciences.10(6):643-51[DOI] 10.7150/ijbs.8974.[PMID] 24948877.
2014
Biological and clinical significance of androgens and androgen receptor in prostate cancer.
International journal of biological sciences.10(6):652-3[DOI] 10.7150/ijbs.9576.[PMID] 24948878.
2014
Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer.
Cancer research.74(8):2362-73[DOI] 10.1158/0008-5472.CAN-13-3058.[PMID] 24509905.
2014
Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.
International journal of biological sciences.10(8):834-45[DOI] 10.7150/ijbs.9406.[PMID] 25076860.
2014
Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.
Cell reports.8(5):1461-74[DOI] 10.1016/j.celrep.2014.07.053.[PMID] 25176644.
2014
Identification of novel GRM1 mutations and single nucleotide polymorphisms in prostate cancer cell lines and tissues.
PloS one.9(7):e103204-[DOI] 10.1371/journal.pone.0103204.[PMID] 25062106.
2014
ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models.
International journal of cancer.135(11):2493-506[DOI] 10.1002/ijc.28919.[PMID] 24752651.
2014
Serum microRNA expression patterns that predict early treatment failure in prostate cancer patients.
Oncotarget.5(3):824-40[DOI] .[PMID] 24583788.
2013
Androgen-responsive serum response factor target genes regulate prostate cancer cell migration.
Carcinogenesis.34(8):1737-46[DOI] 10.1093/carcin/bgt126.[PMID] 23576568.
2013
BMI1, stem cell factor acting as novel serum-biomarker for Caucasian and African-American prostate cancer.
PloS one.8(1):e52993-[DOI] 10.1371/journal.pone.0052993.[PMID] 23308129.
2013
Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications.
International journal of biological sciences.9(7):728-42[DOI] 10.7150/ijbs.6475.[PMID] 23983606.
2013
Glutamate, a metabolic biomarker of aggressiveness and a potential therapeutic target for prostate cancer.
Asian journal of andrology.15(2):212-3[DOI] 10.1038/aja.2012.145.[PMID] 23314660.
2013
Glutamate, glutamate receptors, and downstream signaling pathways.
International journal of biological sciences.9(9):948-59[DOI] 10.7150/ijbs.6426.[PMID] 24155668.
2013
Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.
Journal of cellular physiology.228(11):2127-38[DOI] 10.1002/jcp.24375.[PMID] 23558788.
2013
Reduced mitochondrial DNA content associates with poor prognosis of prostate cancer in African American men.
PloS one.8(9):e74688-[DOI] 10.1371/journal.pone.0074688.[PMID] 24086362.
2013
Resveratrol depletes mitochondrial DNA and inhibition of autophagy enhances resveratrol-induced caspase activation.
Mitochondrion.13(5):493-9[DOI] 10.1016/j.mito.2012.10.010.[PMID] 23088850.
2012
Regulators of gene expression as biomarkers for prostate cancer.
American journal of cancer research.2(6):620-57[DOI] .[PMID] 23226612.
2012
Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research.18(21):5888-901[DOI] 10.1158/1078-0432.CCR-12-1308.[PMID] 23072969.
2012
Serum prosaposin levels are increased in patients with advanced prostate cancer.
The Prostate.72(3):253-69[DOI] 10.1002/pros.21427.[PMID] 21630292.
2011
Aberrant DNA methylation and prostate cancer.
Current genomics.12(7):486-505[DOI] 10.2174/138920211797904061.[PMID] 22547956.
2011
DNA methylome and the complexity of discovering prostate cancer biomarkers.
Asian journal of andrology.13(5):661-2[DOI] 10.1038/aja.2011.90.[PMID] 21725333.
2011
Genetic and epigenetic changes in human prostate cancer.
Iranian Red Crescent medical journal.13(2):80-98[DOI] .[PMID] 22737441.
2010
Androgen receptor signaling and mutations in prostate cancer.
Asian journal of andrology.12(5):639-57[DOI] 10.1038/aja.2010.89.[PMID] 20711217.
2010
Comment on "Effect of transferred NK4 gene on proliferation, migration, invasion, and apoptosis of human prostate cancer DU145 cells" by Dan Yue et al. in Asian Journal of Andrology.
Asian journal of andrology.12(3):444-6[DOI] 10.1038/aja.2010.26.[PMID] 20400970.
2010
Identification of a novel germline missense mutation of the androgen receptor in African American men with familial prostate cancer.
Asian journal of andrology.12(3):336-43[DOI] 10.1038/aja.2010.5.[PMID] 20173765.
2010
Loss of androgen receptor-dependent growth suppression by prostate cancer cells can occur independently from acquiring oncogenic addiction to androgen receptor signaling.
PloS one.5(7):e11475-[DOI] 10.1371/journal.pone.0011475.[PMID] 20628607.
2010
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.
Journal of immunology (Baltimore, Md. : 1950).185(3):1894-902[DOI] 10.4049/jimmunol.1000646.[PMID] 20610652.
2010
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion.
Molecular cancer.9():30-[DOI] 10.1186/1476-4598-9-30.[PMID] 20132547.
2009
Optimal transactivation by Epstein-Barr nuclear antigen 1 requires the UR1 and ATH1 domains.
Journal of virology.83(9):4227-35[DOI] 10.1128/JVI.02578-08.[PMID] 19244333.
2008
Prosaposin is an AR-target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells.
Journal of cellular biochemistry.104(6):2272-85[DOI] 10.1002/jcb.21786.[PMID] 18481277.
2007
Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.
Molecular endocrinology (Baltimore, Md.).21(3):613-24[DOI] .[PMID] 17192406.
2007
Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP.
Journal of cellular biochemistry.101(3):631-41[DOI] .[PMID] 17171640.
2007
Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP).
The Prostate.67(2):178-89[DOI] .[PMID] 17044040.
2007
Survivin is not only a death encounter but also a survival protein for invading tumor cells.
Frontiers in bioscience : a journal and virtual library.12():1260-70[DOI] .[PMID] 17127378.
2006
Pleomorphic adenoma of the trachea in an 8-year-old boy: a case report.
Journal of pediatric surgery.41(8):e23-6[DOI] .[PMID] 16863832.
2005
Amplification and overexpression of prosaposin in prostate cancer.
Genes, chromosomes & cancer.44(4):351-64[DOI] .[PMID] 16080200.
2005
Relationships between reverse transcriptase-polymerase chain reaction for prostate specific antigen, survival, and various prognostic laboratory factors in patients with hormone refractory prostate cancer.
Urologic oncology.23(3):163-7[DOI] .[PMID] 15907715.
2005
Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells.
Asian journal of andrology.7(2):147-58[DOI] .[PMID] 15897971.
2004
Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells.
The Prostate.61(2):114-23[DOI] .[PMID] 15305334.
2004
Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells.
Molecular cancer.3():31-[DOI] .[PMID] 15548330.
2004
Stem cells and prostate cancer.
Clinical prostate cancer.3(1):11-2[DOI] .[PMID] 15279683.
2001
Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways.
Proceedings of the National Academy of Sciences of the United States of America.98(7):4089-94[DOI] .[PMID] 11259649.
2000
The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.
Cancer research.60(2):342-9[DOI] .[PMID] 10667586.
1999
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.
Molecular and cellular biology.19(9):5902-12[DOI] .[PMID] 10454537.
1998
Signaling requirements for oncogenic forms of the Met tyrosine kinase receptor.
Oncogene.17(21):2691-700[DOI] .[PMID] 9840933.
1998
The mutationally activated Met receptor mediates motility and metastasis.
Proceedings of the National Academy of Sciences of the United States of America.95(24):14417-22[DOI] .[PMID] 9826715.
1997
Met and hepatocyte growth factor/scatter factor expression in human gliomas.
Cancer research.57(23):5391-8[DOI] .[PMID] 9393765.
1996
Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration.
Brain research. Molecular brain research.41(1-2):1-7[DOI] .[PMID] 8883928.
1995
Adhesion of human glioma cell lines to fibronectin, laminin, vitronectin and collagen I is modulated by gangliosides in vitro.
Cell adhesion and communication.3(1):27-43[DOI] .[PMID] 7749720.
1995
Extracellular matrix proteins inhibit proliferation, upregulate migration and induce morphological changes in human glioma cell lines.
European journal of cancer (Oxford, England : 1990).31A(3):375-80[DOI] .[PMID] 7540403.
1995
Gangliosides modulate proliferation, migration, and invasiveness of human brain tumor cells in vitro.
Molecular and chemical neuropathology.24(2-3):121-35[DOI] .[PMID] 7632317.
1995
Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro.
International journal of cancer.63(3):450-4[DOI] .[PMID] 7591247.
1995
Synergism between growth-factors in the control of glioma cell-proliferation, migration and invasion in-vitro.
International journal of oncology.6(5):1079-85[DOI] .[PMID] 21556643.
1994
Cell surface gangliosides are involved in the control of human glioma cell invasion in vitro.
Neuroscience letters.177(1-2):44-6[DOI] .[PMID] 7824179.

Office Information

Academic Office
2nd Floor, Faculty Clinic
653 West 8th Street, FC12
Jacksonville, FL 32209
(904) 244-7340
Shahriar.Koochekpour@jax.ufl.edu
Administrative Manager
Sammie Adkins
(904) 244-7340
sammie.adkins@jax.ufl.edu

Education

Medical Degree
1990 · Shiraz University, Shiraz, Iran
Ph.D.
1996 · King's College London, University of London, London, England