Holly L. Hamilton, M.D.

Holly L. Hamilton M.D.

Assistant Professor & Medical Director, UF Health Family Medicine - Amelia Island

Department: Department of Community Health and Family Medicine
Business Phone: (904) 383-1405
Business Email: holly.hamilton@jax.ufl.edu

About Holly L. Hamilton

A native of East Tennessee, Holly Hamilton, M.D., has lived on Amelia Island since 2003. She is happily married with two adult sons, two cats and four rescued Brussels Griffons. A life-long animal advocate, Dr. Hamilton regularly volunteers at pet rescue adoption events. She also enjoys distance running with her local running club and has completed multiple marathons and half marathons. In addition, she is an avid gardener who especially loves to grow fruits, vegetables and herbs.

Clinical Profile

  • Family Medicine


Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.
Molecular therapy : the journal of the American Society of Gene Therapy.21(5):973-85[DOI] 10.1038/mt.2013.31.[PMID] 23439496.
Mating pair formation homologue TraG is a variable membrane protein essential for contact-independent type IV secretion of chromosomal DNA by Neisseria gonorrhoeae.
Journal of bacteriology.195(8):1666-79[DOI] 10.1128/JB.02098-12.[PMID] 23378511.
Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo.
Nucleic acid therapeutics.22(6):380-90[DOI] 10.1089/nat.2012.0389.[PMID] 23181701.
AtlA functions as a peptidoglycan lytic transglycosylase in the Neisseria gonorrhoeae type IV secretion system.
Journal of bacteriology.189(15):5421-8[DOI] .[PMID] 17526702.
In vivo gene expression analysis identifies genes required for enhanced colonization of the mouse urinary tract by uropathogenic Escherichia coli strain CFT073 dsdA.
Infection and immunity.75(1):278-89[DOI] .[PMID] 17074858.
Natural transformation of Neisseria gonorrhoeae: from DNA donation to homologous recombination.
Molecular microbiology.59(2):376-85[DOI] .[PMID] 16390436.
Neisseria gonorrhoeae secretes chromosomal DNA via a novel type IV secretion system.
Molecular microbiology.55(6):1704-21[DOI] .[PMID] 15752195.
Insertion-duplication mutagenesis of neisseria: use in characterization of DNA transfer genes in the gonococcal genetic island.
Journal of bacteriology.183(16):4718-26[DOI] .[PMID] 11466274.
Intestinal multiplication of Mycobacterium paratuberculosis in athymic nude gnotobiotic mice.
Infection and immunity.57(1):225-30[DOI] .[PMID] 2909488.

Office Information

Academic Office
UF Health Family Medicine - Amelia Island
2122 Sadler Road
Fernandina Beach, FL 32034
(904) 383-1396
Office Manager
Christine Royce-Collari
(904) 383-1405


Medical Degree
2000 · East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA
Family Medicine Residency
2003 · East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA